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Shubha Tole

Professor
Department of Biological Sciences
Tata Institute of Fundamental Research
India

Biography

 Dr. Shubha Tole is a Professor of Neurobiology at the Department of Biological Sciences , TIFR.  She deals with Cerebral cortex and the amygdala are the two most complex brain structures. The cortex is responsible for higher brain functions- perception, language, learning, memory; the amygdala is the "emotion center" of the brain. The broad interests of our group are in the genetic and epigenetic mechanisms that control the formation of these highly specialized structures. We use "knockout" and transgenic approaches, in-utero and tissue culture perturbation techniques, ChIP-seq and Mass spectrometry, neurocircuitry tracing and CLARITY-based approaches, and behavioral paradigms to pursue these questions..

Research Interest

 Genetic mechanisms and signaling pathways in developing brain.

Publications

  • Roy A, Gonzalez M, Pierani A, Meyer G,Tole S# (2014)  Lhx2 regulates the development of the forebrain hem system. Cerebral Cortex 5:1361-72

  • Saha B, Hari P, Huilgol D, Tole S (2007)  Dual role for LIM-HD gene Lhx2 in the formation of the lateral olfactory tract (LOT)  Journal of Neuroscience 27: 2290-2297 

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