Sri Rama Koti Ainavarapu
Associate Professor
Department of Chemical Sciences
Tata Institute of Fundamental Research
India
Biography
Dr. A. Sri Rama Koti is an Associate Profesor at the Department of Chemical Sciences . TIFR. His work focuses on Mechanochemistry (chemistry upon mechanical activation of bonds) and kinetic characterization of chemical and biochemical reactions Investigation of mechanical behaviour and functional role of different classes of cell-adhesion biomolecules.Engineering novel proteins with diverse mechanical functions based on cell-adhesionproteins. Elucidation of mechanical unfolding/unfolding pathways of proteins and their relation with biochemical pathways.Development of novel single-molecule assays for protein-protein, protein-DNA, and protein-RNA interactions.
Research Interest
Single-molecule protein mechanics and Chemical biology.
Publications
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Ramanujam V, Kotamarthi HC, Ainavarapu SRK (2014) Ca2+ binding enhanced mechanical stability of an archaeal crystallin PLOS ONE e94513.
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Kotamarthi HC, Narayan S, Ainavarapu SRK (2014) Mechanical Unfolding of Ribose Binding Protein (RBP) and Its Comparison with Other Periplasmic Binding Proteins (PBPs) Journal of Physical Chemistry B 39 pp: 11449-11454
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Kotamarthi HC, Yadav A, Ainavarapu SRK (2015) Small peptide binding stiffens the ubiquitin-like protein SUMO1 Biophysical Journal 2 pp: 360-367.
