Ullas S Kolthur
Associate Professor
Department of Biological Sciences
Tata Institute of Fundamental Research
India
Biography
Dr. Ullas S Kothur is an Associate Professor at TIFR. His work is focused on Metabolic and energy homeostasis play a vital role in governing the cellular pathways. It is important to note that molecular factors involved in these processes are implicated in life-style disorders (diabetes/ obesity), aging and age related diseases (cancer/ neurodegeneration). One of the proteins that directly link metabolic inputs to various molecular events within a cell is Sir2, which was initially identified in yeast as an NAD-dependent HDAC. Sirutins (Sir2-like proteins) play a vital role in cell survival, DNA damage response, cellular differentiation and aging. We use flies, mice and cell culture systems to elucidate the molecular mechanisms regulated by sirtuins. Importantly, we investigate their functions in metabolic and energy homeostasis and also study their role during aging and age-related diseases such as cancer, diabetes and obesity.
Research Interest
Sirtuins: Linking metabolism to aging and cancer.
Publications
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Banerjee KK, Ayyub C, Sengupta S, Kolthur-Seetharam U (2013) Fatbody dSir2 regulates muscle mitochondrial physiology and energy homeostasis via fat metabolism and IIS, and mimics the autonomous functions of dSir2 in muscles. Mol Cell Biol 2 pp: 252-64
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Ho L, Titus AS, Banerjee KK, George S, Lin W, Deota S, Saha AK, Nakamura K, Gut P, Verdin E*, Kolthur-Seetharam U (2013) SIRT4 regulates ATP homeostasis and mediates a retrograde signaling via AMPK. Aging 11 pp: 835-49
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Ghosh S, Banerjee K, Vaidya V, Kolthur-Seetharam U (2016) Early stress history alters serum IGF1 and impairs muscle mitochondrial function in adult male rats. Journal of Neuroendocrinology.
