Manisha Goel
Assistant Professor
Department of Bio Physics
University of Delhi
India
Biography
Ph.D. National Institute of Immunology 1998-2003 PG M.Sc (Biotechnology), University of Roorkee, Roorkee (U.P.) 1996-1998 UG B.Sc (Zoology, Botany, Chemistry), HNB Garhwal University 1993-1996
Research Interest
We aim to address the biological pathways and processes with a “systems biology” approach via high throughput data processing. My research interests include Structural Biology, Computational Biology and Bioinformatics. We are interested in understanding the relationship between protein structure, function and evolution in various biological systems, particularly extremophiles. For exploring this relationship we use various biochemical and biophysical techniques like X-ray crystallography to determine the protein structures. We often use bioinformatics analysis to predict function, properties and/or structure of either protein components alone or as part of the biochemical Faculty Details proforma for DU Web-site www.du.ac.in Page 2 pathways. The major protein systems that we are currently working on are CRISPR-Cas proteins, archaeal chaperones and intra-molecular chaperones found in various protein families.
Publications
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Verma VV, Gupta R, Goel M. (2015) Phylogenetic and evolutionary analysis of functional divergence among Gamma glutamyl transpeptidase (GGT) subfamilies. Biol Direct. Sep 14;10:49
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Singh Y, Gupta N, Verma VV, Goel M, Gupta R. (2016) Selective disruption of disulphide bonds lowered activation energy and improved catalytic efficiency in TALipB from Trichosporon asahii MSR54: MD simulations revealed flexible lid and extended substrate binding area in the mutant. Biochem Biophys Res Commun. Mar 25;472 (1):223-30.
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Rani S, Srivastava A, Kumar M, Goel M. (2016) CrAgDb--a database of annotated chaperone repertoire in arachaeal genomes. FEMS Microbiol Lett. Mar; 363 (6).
