Ali Akbar Saboury
Department of Biophysics
Tehran University of Medical Science
Ali Akbar Saboury was born in July 1960 in Kashmar, in the North-East of Iran. He completed his Ph.D. in Physical Chemistry in 1996. Now, he is professor and the head of Biophysics in institute of biochemistry and biophysics,university of Tehran. He researches on the protein denaturation thermodynamically and the enzyme kinetic using spectroscopy and microcalorimetry techniques. He supervises research works leading to the degree of M.Sc and Ph.D. He is associate member of Abdus-Salam International Center for Theoretical Physics (ICTP; Triest, Italy) and actives in many international societies and journals.
Studies on thermodynamic aspects of protein denaturation with the aim of obtaining additional information regarding protein structure-function relationship. Protein denaturation is done in many ways including thermal denaturation, chemical denaturation (by urea or guanidine hydrochloride), solvent denaturation, salt denaturation and interaction of proteins with surfactants. Different techniques such as equilibrium dialysis, isothermal titration microcalorimetry, differential scanning calorimetry, spectroscopy and densiometry are used for this purpose. Also kinetics of activation and inactivation of enzymes attached to ligands (inhibitor, activator, denaturant) and comparative studies related to kinetic and thermodynamic parameter involved.
Daneshgar P, Moosavi-Movahedi AA, Norouzi P, Ganjali MR, Madadkar-Sobhani A, Saboury AA. Molecular interaction of human serum albumin with paracetamol: spectroscopic and molecular modeling studies. International journal of biological macromolecules. 2009 Aug 1;45(2):129-34.
Divsalar A, Bagheri MJ, Saboury AA, Mansoori-Torshizi H, Amani M. Investigation on the interaction of newly designed anticancer Pd (II) complexes with different aliphatic tails and human serum albumin. The Journal of Physical Chemistry B. 2009 Sep 24;113(42):14035-42.
Mansouri-Torshizi H, Mahboube I, Divsalar A, Saboury AA. 2, 2′-Bipyridinebutyldithiocarbamatoplatinum (II) and palladium (II) complexes: synthesis, characterization, cytotoxicity, and rich DNA-binding studies. Bioorganic & medicinal chemistry. 2008 Nov 1;16(21):9616-25.
Nafisi S, Saboury AA, Keramat N, Neault JF, Tajmir-Riahi HA. Stability and structural features of DNA intercalation with ethidium bromide, acridine orange and methylene blue. Journal of Molecular Structure. 2007 Feb 17;827(1):35-43.