Azra Rabbani Chadegani
Institute of Biochemistry and Biophysics
Tehran University of Medical Science
PhD in Biochemistry from University of London, Chester Beatty Reseerch Institute in 1979, Presently working as professor at University of Tehran
The research in this laboratory is organized aroud three major themes involving chromatin structure and function. (i) Interaction of anticancer drugs with chromatin, DNA and chromatin proteins, histones and nonhistone proteins, in solution, normal cell e.g. Bone marrow cells and cancer cells using biochemical and biophysical approaches. (ii) The effect of anticancer drugs on epigenetic, gene expression and apoptosis. (iii) The effect of heavy metals such as lead, nickel and chromium as a potent environmental poisons on normal cells e.g. alveolar macrophages, hepatocytes and bone marrow cells (stem cells). Also the interaction of these metals with DNA, nucleosomes and chromatin proteins (histones and HMG proteins), alteration of chromatin structure and epigenetic effects are investigated.
4) Rabbani-Chadegani A, Abdossamadi S, Bargahi A, Yousef-Masboogh M. Identification of low-molecular-weight protein (SCP1) from shark cartilage with anti-angiogenesis activity and sequence similarity to parvalbumin. Journal of pharmaceutical and biomedical analysis. 2008 Feb 13;46(3):563-7.
3) Rabbani-Chadegani A, Chamani E, Hajihassan Z. The effect of vinca alkaloid anticancer drug, vinorelbine, on chromatin and histone proteins in solution. European journal of pharmacology. 2009 Jun 24;613(1):34-8.
2) Rabbani-Chadegani A, Chamani E, Hajihassan Z. The effect of vinca alkaloid anticancer drug, vinorelbine, on chromatin and histone proteins in solution. European journal of pharmacology. 2009 Jun 24;613(1):34-8.
1) Hajihassan Z, Rabbani-Chadegani A. Studies on the binding affinity of anticancer drug mitoxantrone to chromatin, DNA and histone proteins. Journal of biomedical science. 2009 Mar 11;16(1):31.