Orla L Howe
Lecturer & Research Scientist
Biological Sciences
Dublin Institute of Technology
Ireland
Biography
PhD with Trinity College Dublin in 2000-2004, in conjunction with the Queensland Institute of Medical Research in Brisbane, Australia (2002-2004). Obtained two student awards with the Radiation Research Society during this time (2001 in San Juan, Puerto Rico, 2002 in Reno, Nevada)). Worked as a postdoctoral research scientist in the Radiation and Environmental Science Centre (RESC) from 2004-2005. Awarded a DIT Arnold Graves fellowship in 2005 to conduct research until 2008 in the RESC. Received a scholar in Training (SIT) award with the Radiation Research Society in Sept 2008 for the research work conducted during this fellowship. Currently working as a research scientist in RESC and a lecturer in the School of Biological Sciences in DIT Kevin St.
Research Interest
Radiation safety. Telomere shortening and bridge formation coupled with mitochondrial dysfunction. Intrinsic radiosensitivity of individuals
Publications
-
Gueven N, Becherel OJ, Howe O, Chen P, Haince JF, Ouellet ME, Poirier GG, Waterhouse N, Fusser M, Epe B, de Murcia JM, de Murcia G, McGowan CH, Parton R, Mothersill C, Grattan-Smith P, Lavin MF. A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance. 2007. Cell • Howe O, O’Malley K, Lavin M, Gardiner F, Seymour C, Quinlan D, Mulvin D, Mothersill C.Cell death mechanisms associated with G2 chromosomal radiosensitivity: A cohort study in patients with prostate cancer and benign prostatic hyperplasia, 2005. Radiation Research, 164(5):627-634.
-
Gorman S, Tosetto M, Dunlop A, Lyng F, Howe O, Sheahan K, O’Donoghue D, Hyland J, Mulcahy H, O’Sullivan J. Radiation and chemotherapy bystander effects induce early genomic instability events: telomere shortening and bridge formation coupled with mitochondrial dysfunction. 2009. Mutation Research 669(1-2):131-8.
