Paul Dowling
Lecturer
Department of Biology
National University of Maynooth
Ireland
Biography
Career profile (Education and Employment): • BSc (University College Dublin, Pharmacology Dept.) • PhD (NUI Maynooth, Biology Dept.) Academic Experience: • Lecturing, Practical class supervision, Workgroup supervision: University College Dublin, Pharmacology Dept. 2001-2002 • Lecturing, Practical class supervision, Workgroup supervision: NUI Maynooth, Biology Dept. 2002-2003 • Lecturing, Supervision of post-graduate students, Practical class supervision, Workgroup supervision: Dublin City University, NICB. 2004-2013 • Lecturing, Practical class supervision, Workgroup supervision: NUI Maynooth, Biology Dept. 2013- Research Experience: • 3 years University College Dublin, Pharmacology Dept. (Muscular Dystrophy) • 1 year NUI Maynooth, Biology Dept. (Muscular Dystrophy; Myasthenia Gravis) • 9 years Dublin City University, NICB. (Cancer; Diabetes; Muscle biology) Research Funding & Awards: Ongoing Research Support: Enterprise Ireland CF 2012 2005 - 01/10/2012-30/09/2013 “New Serum Biomarkers for Early Detection of Lung Cancer”. Role: PI, Award: €106,493 Mater Hospital Foundation, Serum protein biomarkers for drug response in Multiple Myeloma patients 2006-2013 Role: Joint PI, Award: €230,000 Completed Research Support Enterprise Ireland PC/2008/0368 - 01/01/2009-31/12/2010 “Validation of a panel of serum biomarkers for use in early detection and monitoring of response to therapy in squamous cell carcinoma of the lung”. Role: Joint PI, Award: €100,000 Currently supervising: 5 Andrew McCann (PhD, DCU): Analysis of conditioned media from cancer cell lines as a source of candidate biomarkers for early detection and therapeutic monitoring. Catriona Hayes (PhD, Mater/Dana Farber): Analysis of the interactions between plasma cells with the micro-environment and its role in Bortezomib resistance. MinYuen Teo (MD, St Vincents/Tallaght): Identification of biomarkers for the early detection of recurrence in colorectal cancer patients. Kay Reen Ting (MD, Mater): Investigating biomarkers predicting response to Bortezomib in Multiple Myeloma patients. Benvon Moran (MD, St James): Examining molecular mechanisms involved in the progression of malignant melanoma. Previously supervised: 1 Rajesh Rajpal (PhD, Mater): Identification of novel protein biomarkers for predicting response to thalidomide-based therapy in newly diagnosed multiple myeloma patients (2007-2011) Damian Pollard (PhD, DCU): Identification of biomarkers for the early detection and therapeutic monitoring in lung cancer (2007-2013).
Research Interest
Multiple Myeloma, Malignant Melanoma, Identification of novel protein biomarkers for predicting response to thalidomide-based therapy in newly diagnosed multiple myeloma patients.
Publications
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Holland A, Schmitt-John T, Dowling P, Meleady P, Henry M, Clynes M, Ohlendieck K (2014) 'Intricate effects of primary motor neuronopathy on contractile proteins and metabolic muscle enzymes as revealed by label-free mass spectrometry'. BIOSCIENCE REPORTS, 34 :331-343
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O'Sullivan D, Henry M, Joyce H, Walsh N, Auley EM, Dowling P, Swan N, Moriarty M, Barnham P, Clynes M, Larkin A (2014) '7B7: a novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells'. TUMOR BIOLOGY, 35 :6983-6997
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Paul Dowling, Martin Clynes, and Paula Meleady (2011) 'Clinical Research and Applications: Sample Preparation Techniques for Cancer Proteomics' In: Sample Preparation in Biological Mass Spectrometry. Springer.
