David Hoey
Associate Professor
Mechanical & Manufacturing Engineering
Trinity College Dublin
Ireland
Biography
Dr. David Hoey is an Associate Professor in Biomedical Engineering within the Department of Mechanical and Manufacturing Engineering and PI within the Trinity Centre for Bioengineering in Trinity College Dublin (TCD). Dr. Hoey leads a multidisciplinary experimental mechanobiology research group where his goal is to integrate engineering mechanics into the understanding of the molecular basis of physiology and disease. Dr. Hoey's research has discovered novel mechanisms by which bone can sense and respond to a biophysical stimulus. In particular, he is focused on determining indirect and direct biophysical regulation of mesenchymal stem cell contributions to bone formation and repair and how this is altered in disease. These platforms have potential to result in new therapeutics that mimic the beneficial effect of biophysical stimuli and treat orthopaedic diseases such as osteoporosis and osteoarthritis. In 2009 Dr. Hoey received his PhD in Bioengineering from the Trinity Centre for Bioengineering and went on to complete postdoctoral fellowships in Columbia University in the US and the Royal College of Surgeons in Ireland under the Marie-Curie/IRCSET programme. In 2012 he joined the University of Limerick as a Lecturer and was awarded the European Research Council Starting Grant in 2013 to explore the role the primary cilium in stem cell mechanobiology in bone and has recently returned to TCD in 2015 as Associate Professor to continue this work.
Research Interest
BIOMATERIALS; BIOMECHANICS; Biomechanics, Biomedical Engineering; BONE ABNORMALITIES; BONE ADAPTATION; BONE CEMENT; BONE MASS; BONE METASTASIS; BONE REGENERATION; bone remodelling and repair; CELL BIOMECHANICS; MECHANOBIOLOGY; MESENCHYMAL STEM CELLS; Promotion of Bone Health throgh Exercise; Stem Cell Biology
Publications
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Herzog, F.A., Geraedts, J., Hoey, D., Jacobs, C.R., A mathematical approach to study the bending behavior of the primary cilium, Proceedings of the 2010 IEEE 36th Annual Northeast Bioengineering Conference, NEBEC 2010, 2010
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Lee, K.L., Hoey, D.A., Jacobs, C.R., Primary cilia-mediated mechanotransduction in bone, Clinical Reviews in Bone and Mineral Metabolism, 8, (4), 2010, p201-212
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Hoey D and Taylor D, The effect of mixing technique on fatigue of bone cement when stress concentrations are present., International Journal of Nano and Biomaterials, 3, 2010, p36 - 48
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Hoey, D.A., Jacobs, C.R., Oscillatory fluid flow affects the osteogenic differentiation of human bone marrow stromal cells in a primary cilium dependent manner, ASME 2011 Summer Bioengineering Conference, SBC 2011, (PARTS A AND B), 2011, p331-332
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Grande D., Shah N., Catanzano A., Nelson F., Hoey D., Hoey D., Jacobs C., On the horizon from the ORS, Journal of the American Academy of Orthopaedic Surgeons, 19, (1), 2011, p59-62
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Hoey, D.A., Kelly, D.J., Jacobs, C.R., A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cells. , Biochemical and Biophysical Research Communications, 412, (1), 2011, p182-187
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Hoey, D.A., Downs, M.E., Jacobs, C.R., The mechanics of the primary cilium: An intricate structure with complex function, Journal of Biomechanics, 45, (1), 2012, p17-26
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Jacobs C, Downs M, Nguyen A, Herzog F, Hoey D, Mechanical behavior of primary cilia., 2012
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Hoey D., Hoey D., Hoey D., Chen J., Jacobs C., The primary cilium as a novel extracellular sensor in bone, Frontiers in Endocrinology, 3, (JUN), 2012
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Hoey D., Hoey D., Hoey D., Tormey S., Ramcharan S., O Brien F., O Brien F., Jacobs C., Primary cilia-mediated mechanotransduction in human mesenchymal stem cells, Stem Cells, 30, (11), 2012, p2561-2570
