Ed Lavelle
Professor
School of Biochemistry and Immunology
Trinity College Dublin
Ireland
Biography
Dr Ed Lavelle graduated with a BSc in Microbiology from University College Galway in 1990 and a PhD in Immunology from the University of Plymouth in 1994. He carried our postdoctoral research at the University of Nottingham on nano and microparticles as vaccine adjuvants. This was followed by further postdoctoral positions at the Rowett Research Institute (Aberdeen) and Trinity College Dublin on vaccine adjuvants and immunomodulators. He was appointed as a lecturer in Immunology in 2004, senior lecturer in 2012 and is a Principal Investigator in the School of Biochemistry and Immunology. His research focuses on the development and mode of action of particulate adjuvants for injectable and mucosal vaccines. The group works closely with a number of Biotech companies and Pharma engaged in vaccine research. Dr Lavelle’s work in AMBER concerns (1) the relationship between the physicochemical properties of biomaterials and their capacity to induce inflammatory and wound healing responses and (2) the development of innovative oral capsule (SmPill®) systems for oral vaccines. This work is a collaboration with Sigmoid Pharma Ltd, an innovative drug delivery company based in Dublin.
Research Interest
Biochemistry and Immunology.
Publications
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Arancibia, S., Espinoza, C., Salazar, F., Del Campo, M., Tampe, R., Zhong, T-Y., De Ioannes, P., Moltedo, B., Ferreira, J., Lavelle, E.C., Manubens, A., De Ioannes, A.E. and Becker, M.I. (2014). A novel immunomodulatory hemocyanin from the limpet Fissurella latimarginata promotes potent anti-tumor activity in melanoma. PLOS One 9, 1:e87240. (IF 3.2).
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Oleszycka, E. and Lavelle, E.C. (2014). The immunomodulatory properties of the vaccine adjuvant alum. Current Opinion in Immunology. 28C, 1-5. (IF 7.9).
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Doyle, S.L., Ozaki, E., Brennan, K., Humphries, M.M., Mulfaul, K., James Keaney, J., Kenna, P.F., Maminishkis, A., Kiang A-S., Saunders, S.P., Hams, E., Lavelle, E.C., Gardiner, C., Fallon, P.G., Adamson, P., Humphries, P. and Campbell, M (2014). IL-18 attenuates experimental choroidal neovascularization (CNV) representing a therapy for the prevention of wet age-related macular degeneration (AMD). Science Translational Medicine. 6, 230ra44. (IF 14,4)
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Meraz, I.M., Hearnden, C.H.A., Liua, X., Yang, M., Williams, L., Gua, J., Rhudy, J.R., Yokoi, K., *Lavelle, E.C. and *Serda, R.E (joint senior authors). (2014). Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization increasing the anti-tumor efficacy of doxorubicin nanoliposomes. PLOS One. 9(4):e94703. (IF 3.2)
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Abautret-Daly, A., Davitt, C. and Lavelle, E.C. (2014). Harnessing the antibacterial and immunological properties of mucosal-associated invariant T cells in the development of novel oral vaccines against enteric infections. Biochemical Pharmacology. 92, 2, 173-83. (IF 4.7).
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Kearney, C.J., Cullen, S.P., Tynan, G.A., Henry, C.M., Clancy, D., Lavelle, E.C. and Martin, S.J. (2015). Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production. Cell Death and Differentiation. doi: 10.1038/cdd.2014.222. (IF 8.4).
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Davitt, C. and Lavelle, E.C. (2015). Delivery strategies to enhance oral vaccination against enteric infections. Advanced Drug Delivery Reviews. 91:52-69. (IF 15.0).
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Brown, A.F., Murphy, A.G., Lalor, S.J., Leech, J.M., O’Keeffe, K.M., Mac Aogáin, M., O’Halloran, D.P., Lacey, K., Tavakol, M., Hearnden, C.H., Fitzgerald-Hughes, D., Humphreys, H., Fennell, J.P., van Wamel, W., Foster, T.J., Geoghegan, J.A., Lavelle, E.C., Rogers, T.R. and McLoughlin, R.M. (2015) Memory Th1 cells are protective in invasive Staphylococcus aureus infection. PloS Pathogens. 11(11):e1005226. (IF 7.6).
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Oleszycka, E., Moran, H.B.T., Tynan, G.A., Hearnden, C.H., Coutts, G., Campbell, M., Allan, S.M., Scott, C.J. and Lavelle, E.C. (2016). IL-1α and inflammasome-independent IL-1β promote neutrophil infiltration following alum vaccination. FEBS Journal. 283, 1, 9-24. (IF 4.0)
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Finlay, C.M., Stefanska, A.M., Walsh, K.P., Doyle, B., Boon, L., Lavelle, E.C.,Walsh, P.T. and Mills, K.H.G (2016). Helminth-induced IL-33 and IL-5 protects against autoimmunity. The Journal of Immunology. 196, 2, 703-14. (IF 4.9).
