Frederick Sheedy
Assistant Professor
Biochemistry
Trinity College Dublin
Ireland
Biography
I recently established my independent research group within the School of Biochemistry & Immunology at Trinity College, Dublin (TCD), Ireland, examining macrophage function in health and disease. This builds upon my established expertise in innate immunity, lipid metabolism and molecular regulation by miRNA. I pioneered miRNA research in the field of innate immunity during my graduate studies in the O'Neill Lab, resulting in a Nature Immunology first author publication and this emerging field was highlighted by a Nature Reviews Immunology article, which I co-wrote. I obtained a postdoctoral fellowship from the American Heart Association to study the molecular mechanisms of inflammation in disease at NYU. This transformative work was published in Nature Immunology and alongside my recent work on tuberculosis, funded by a Starting Investigator grant from Science Foundation Ireland, fuelled my interest in macrophage-driven disease. My current work pioneers new lines of investigation in the emerging field of immunometabolism and macrophage function during diseases such as cancer and infection.
Research Interest
bacteriology, host-pathogen interaction, immune system, immunochemistry, immunodeficiency diseases, immunology, immunotherapy,infectious diseases,Lipid metabolism,tumor immunology,vaccine
Publications
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Rayner, K.J., Esau, C.C., Hussain, F.N., McDaniel, A.L., Marshall, S.M., Van Gils, J.M., Ray, T.D., Sheedy, F.J., Goedeke, L., Liu, X., Khatsenko, O.G., Kaimal, V., Lees, C.J., Fernandez-Hernando, C., Fisher, E.A., Temel, R.E., Moore, K.J., Inhibition of miR-33a/b in non-human primates raises plasma HDL and lowers VLDL triglycerides, Nature, 478, (7369), 2011, p404-407
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Rayner, K.J., Sheedy, F.J., Esau, C.C., Hussain, F.N., Temel, R.E., Parathath, S., Van Gils, J.M., Rayner, A.J., Chang, A.N., Suarez, Y., Fernandez-Hernando, C., Fisher, E.A., Moore, K.J., Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis, Journal of Clinical Investigation, 121, (7), 2011, p2921-2931
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O Neill, L.A., Sheedy, F.J., McCoy, C.E., MicroRNAs: The fine-tuners of Toll-like receptor signalling, Nature Reviews Immunology, 11, (3), 2011, p163-175
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Sheedy, F.J., Moore, K.J., IL-1 signaling in atherosclerosis: Sibling rivalry, Nature Immunology, 14, (10), 2013, p1030-1032
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Moore, K.J., Sheedy, F.J., Fisher, E.A., Macrophages in atherosclerosis: A dynamic balance, Nature Reviews Immunology, 13, (10), 2013, p709-721
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Sheedy, F.J., Grebe, A., Rayner, K.J., Kalantari, P., Ramkhelawon, B., Carpenter, S.B., Becker, C.E., Ediriweera, H.N., Mullick, A.E., Golenbock, D.T., Stuart, L.M., Latz, E., Fitzgerald, K.A., Moore, K.J., CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation, Nature Immunology, 14, (8), 2013, p812-820
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Ramkhelawon, B., Hennessy, E.J., Ménager, M., Ray, T.D., Sheedy, F.J., Hutchison, S., Wanschel, A., Oldebeken, S., Geoffrion, M., Spiro, W., Miller, G., McPherson, R., Rayner, K.J., Moore, K.J., Netrin-1 promotes adipose tissue macrophage retention and insulin resistance in obesity, Nature Medicine, 20, (4), 2014, p377-38
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Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, van den Bosch MW, Quinn SR, Domingo-Fernandez R, Johnson DG, Jiang J, Israelsen WJ, Keane J, Thomas C, Clish C, Vanden Heiden M, Xavier RJ, O Neill LA, Pyruvate Kinase M2 Regulates Hif-1alfa Activity and IL-1ß Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages., Cell metabolism, 21, (1), 2015, p65-80
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Sheedy, F.J., Turning 21: Induction of miR-21 as a key switch in the inflammatory response, Frontiers in Immunology, 6, (JAN), 2015
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Ouimet, M., Ediriweera, H.N., Mahesh Gundra, U., Sheedy, F.J., Ramkhelawon, B., Hutchison, S.B., Rinehold, K., Van Solingen, C., Fullerton, M.D., Cecchini, K., Rayner, K.J., Steinberg, G.R., Zamore, P.D., Fisher, E.A., Loke, P., Moore, K.J., MicroRNA-33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis, Journal of Clinical Investigation, 125, (12), 2015, p4334-4348
