Michael Monaghan
Assistant Professor
Mechanical & Manufacturing Engineering
Trinity College Dublin
Ireland
Biography
Dr. Michael Monaghan is an Ussher Assistant Professor in Biomedical Engineering at Trinity College Dublin, the University of Dublin Dr. Monaghan performed his Postdoctoral research in Germany as a recipient of a prestigious Marie Curie Individual Fellowship. His research was coordinated between the Department of Cell and Tissue Engineering in the Fraunhofer Institute for Interfacial Engineering and Biotechnology and the Department of Women's Health in University Clinic Tubingen. During this period he has published a number of key papers in the field of human valvulogenesis, embryonic stem cell research, cardiomyocyte differentiation, biomaterials and non-invasive optical characterisation (Raman microspectroscopy, fluorescent lifetime imaging (FLIM), multiphoton and second harmonic generation (SHG) imaging). Dr. Monaghan received both his B.Eng (Biomedical) and Ph.D. (Biomedical Engineering) from the National University of Ireland Galway (NUIG).During his Ph.D. Dr. Monaghan received a number of research awards such as travel awards from the European Molecular Biology Organisation (EMBO) and the German Academic Exchange Service (DAAD), and the 2015 Julia Polak European Doctorate Award in recognition of the achievements made during his Ph.D. Dr. Monaghan is actively involved in the tissue engineering and regenerative medicine international society (TERMIS) as Chair-Elect of the EU Student and Young Investigator Section, and was recently promoted to EU Chair of this section. Lab Website: www.monaghanlab.com
Research Interest
2ND HARMONIC GENERATION; 3D Imaging Analysis; Bioengineering and radiologic imaging; BIOMATERIALS; COLLAGEN; CONFOCAL IMAGING; Confocal photoluminescence imaging; DRUG TARGETING; DRUG-DELIVERY SYSTEM; EXTRACELLULAR MATRIX (ECM); GENE SILENCING; GENE-THERAPY
Publications
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Dash, B.C., Réthoré, G., Monaghan, M., Fitzgerald, K., Gallagher, W., Pandit, A., The influence of size and charge of chitosan/polyglutamic acid hollow spheres on cellular internalization, viability and blood compatibility, Biomaterials, 31, (32), 2010, p8188-8197
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Monaghan, M. Browne, S. Wang, W. Pandit, A.(ed.), Scaffold mediated non-viral inhibition of collagen type I and type III in cardiac fibroblasts, 2011
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Monaghan M, Greiser U, Cao H, Wang W, Pandit A, A ligand enhanced dendritic PEGylated poly (2-(dimethylamino) ethyl diacrylate) as a vehicle of microRNA, Drug Delivery and Translational Research, 2, 2011, p406 - 414
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Monaghan, M. Holladay, C. Pandit, A.(ed.), A crosslinked collagen type i biomaterial reservoir for non-viral gene delivery in vivo, 2011
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Monaghan, M., Pandit, A., RNA interference therapy via functionalized scaffolds, Advanced Drug Delivery Reviews, 63, (4), 2011, p197-208
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Monaghan, M., Greiser, U., Wall, J.G., O Brien, T., Pandit, A., Interference: An alteRNAtive therapy following acute myocardial infarction, Trends in Pharmacological Sciences, 33, (12), 2012, p635-645
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Michael Monaghan, An injectable collagen scaffold delivering exogenous microRNA as a therapy to modulate extracellular matrix remodelling , NUI Galway, 2013
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Energy Regeneration systems in cell free protein synthesis in vitro in, editor(s)Bethaz C, Li Puma V , New Research on Protein Synthesis, Nova Science Publishers, Inc, 2013, pp67 - 76, [2. Kahlig A, Schwedhelm I, Monaghan M, Thein M, Hansmann J]
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Monaghan, Michael, Browne, Shane, Schenke-Layland, Katja, Pandit, Abhay, A Collagen-based Scaffold Delivering Exogenous MicroRNA-29B to Modulate Extracellular Matrix Remodeling, Molecular Therapy, 22, (4), 2014, p786-796
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Monaghan, M., Augspurger, C., Brauchle, E., Lakner, P., Breunig, G., Konig, K., Schenke-Layland, K., Fluorescent live time imaging from pluripotency to differentiation in mouse embryonic stem cells reveals endogenous autofluorescence profiles, Journal of Tissue Engineering and Regenerative Medicine, 8, 2014, p300-301
