Shigeki Nakagome
Assistant Professor
Psychiatry
Trinity College Dublin
Ireland
Biography
Shigeki Nakagome is Ussher Assistant Professor in Genomic Medicine at School of Medicine. Dr. Nakagome received his Ph.D. at The University of Tokyo in 2010 with the focus on the evolutionary model in which high risk variants associated with Crohn's disease at the NOD2 locus may have exclusively spread into European populations by natural selection. As a postdoctoral researcher, Dr. Nakagome first joined The Institute of Statistical Mathematics from 2011 to 2014 where he was awarded a competitive Research Fellowship of the Japan Society for the Promotion of Science (JSPS) for Young Scientists and developed a new statistical method that incorporates kernel methods into Approximate Bayesian Computation (kernel ABC). Dr. Nakagome obtained further postdoctoral training on experimental aspects of functional genomics at The University of Chicago from 2013 to 2016 as JSPS Overseas Research Fellow. During this training, Dr. Nakagome has acquired expertise in population and functional genomics to develop statistical approaches for understanding selective pressures on immunity genes and to connect genetic polymorphisms to their functional consequences in the immune system.
Research Interest
AYESIAN COMPUTATION; Bioinformatics; Evolution; Evolutionary Biology; Evolutionary genetics; GENE POLYMORPHISMS; GENE REGULATION; GENE-EXPRESSION; Genomes, Genomics; Genomic structure and function, molecular approaches to gene function; Genomics; Host-pathogen interaction; Human Evolution; Human Population Genetics; INFLAMMATORY BOWEL DISEASE; microbiome; MOLECULAR EVOLUTION; POPULATION GENETICS
Publications
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Kariuki SN, Blischak JD, Nakagome S, Witonsky DB, Di Rienzo A, Patterns of Transcriptional Response to 1,25-Dihydroxyvitamin D3 and Bacterial Lipopolysaccharide in Primary Human Monocytes., G3 (Bethesda, Md.), 6, (5), 2016, p1345-55
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Nakagome S, Chinen H, Iraha A, Hokama A, Takeyama Y, Sakisaka S, Matsui T, Kidd JR, Kidd KK, Said HS, Suda W, Morita H, Hattori M, Hanihara T, Kimura R, Ishida H, Fujita J, Kinjo F, Mano S, Oota H, Confounding effects of microbiome on the susceptibility of TNFSF15 to Crohn's disease in the Ryukyu Islands., Human Genetics, 2017
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Alleyne D, Witonsky DB, Mapes B, Nakagome S, Sommars M, Hong E, Muckala KA, Di Rienzo A, Kupfer SS, Colonic transcriptional response to 1,25(OH)2 vitamin D3 in African- and European-Americans., The Journal of Steroid Biochemistry and Molecular Biology, 168, 2017, p49 - 59
