University College Dublin
Working as professor at University college of Dublin, Ireland in Chemistry Department. Completed PhD in Chemistry Since 10.2016: College Lecturer/Assistant Professor in Organic Chemistry and Chemical Biology at UCD, School of Chemistry. 03-09.2016: Senior Scientist at the ETH Zurich, Department of Molecular Biology and Biophysics. 2012-2016: Independent Group Leader at the University of Konstanz, Department for Organic Chemistry/Cellular Chemistry. 2008-2011: Post-Doctoral Fellow in the Group of Prof. Dr. A. Marx, University of Konstanz, Department for Organic Chemistry/Cellular Chemistry. 2005-2008: Post-Doctoral Fellow in the Group of Prof. Dr. A. Skerra, Technical University of Munich, Department of Biological Chemistry. 2001-2004: Doctoral Thesis in the Group of Prof. Dr. R. Huber, MPI for Biochemistry, Department for Structural Biology (Supervisor: Prof. Dr. N. Budisa). 2000-2001: Scientific work at the C.R.I.B.I. Biotechnology Centre, University of Padua (Italy), Department of Protein Chemistry. 1999-2000: Diploma Thesis in the Group of Prof. Dr. R. Rocchi, University of Padua (Italy), Department of Organic Chemistry.
Main research interests concerns the engineering of post-translational modifications such as glycosylations. Glycoproteins are of special interest not only because of their huge therapeutic potential, but also because there is still limited understanding of the oligosaccharide's function. Most therapeutic proteins are post-translational glycosylated; therefore, recombinant glycoproteins are mainly expressed in eukaryotic cells. Many of these eukaryotic systems suffer from high production costs and display a heterogeneous glycosylation pattern that complicates the elucidation of the oligosaccharide functions.