Molecular Microbiology & Biotechnology
Tel Aviv University
Daniel Segal, Professor, Molecular Microbiology & Biotechnology, Tel Aviv University, Israel
Develop and screen in vivo novel small molecules as amyloid-beta and tau inhibitors in Alzheimer’s disease. Develop and screen natural plant compounds as amyloid-beta and tau inhibitors in Alzheimer’s disease. Develop and screen in vivo novel small molecules as alpha-synuclein inhibitors in Parkinson’s disease Develop and screen in vivo novel small molecules as TDP-43 inhibitors in ALS. Examine the mechanism of spreading of TDP-43 in ALS. Examine the role of protein glycosylation in the aging and neurodegenerative brain. Study misfolding of the tumor suppressor proteins p53 and VHL and develop small molecules for restoring their folding and function.
Frydman-Marom, A., Convertino, M., Pellarin, R., Lampel, A., Shaltiel-Karyo, R., Segal, D., Caflisch, A., Shalev , D.E., and Gazit, E. (2011). Structural basis for inhibiting beta-Amyloid oligomerization by a non-coded beta-breaker substituted endomorphin analogue. ACS Chemical Biology, 6(11):1265-76.
Frydman-Marom, A., Levin, A., Farfara, D., Benromano, T., Scherzer-Attali, R., Peled, S., Vassar, R., Segal, D., Gazit, E., Frenkel, D., and Ovadia, M. (2011). Orally administrated cinnamon extract reduces beta-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models. PLoS One, 6(1): e16564.