Daniel Wreschner
Cell Research & Immunology
Professor
Tel Aviv University
Israel
Biography
Daniel Wreschner, Professor, Cell Research & Immunology, Tel Aviv University
Research Interest
Molecular analysis of the human cancer cell with special emphasis on membrane proteins, tumor-associated antigens, ligand-receptor interactions and cell signaling. We work on a breast-cancer associated protein designated MUC1 (CA-15-3) that is a membrane protein participating in cell signaling.
Publications
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Pichinuk E, Broday L, Wreschner DH. Endogenous RNA cleavages at the ribosomal SRL site likely reflect miRNA (miR) mediated translational suppression. Biochem Biophys Res Commun. 2011 Nov 4;414(4):706-11. doi: 10.1016/j.bbrc.2011.09.140. Epub 2011 Oct 6. PubMed PMID: 22001924.
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Margalit M, Yogev L, Yavetz H, Lehavi O, Hauser R, Botchan A, Barda S, Levitin F, Weiss M, Pastan I, Wreschner DH, Paz G, Kleiman SE. Involvement of the prostate and testis expression (PATE)-like proteins in sperm-oocyte interaction. Hum Reprod. 2012 May;27(5):1238-48. doi: 10.1093/humrep/des064. Epub 2012 Mar 8. PubMed PMID: 22402205; PubMed Central PMCID: PMC3329192.
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Pichinuk E, Benhar I, Jacobi O, Chalik M, Weiss L, Ziv R, Sympson C, Karwa A, Smorodinsky NI, Rubinstein DB, Wreschner DH. Antibody targeting of cell-bound MUC1 SEA domain kills tumor cells. Cancer Res. 2012 Jul 1;72(13):3324-36. doi: 10.1158/0008-5472.CAN-12-0067. Epub 2012 Apr 16. PubMed PMID: 22507854.
