Molecular Microbiology & Biotechnology
Tel Aviv University
Gil Segal,Professor, Molecular Microbiology & Biotechnology, Tel Aviv University, Israel
The projects in the lab focus on different aspects of pathogen-host interactions. Current project include, among others, the identification of host cell processes modulated by bacterial pathogenesis determinants; uncovering the regulatory network that controls the expression of pathogenesis related genes; applying functional genomics to decipher the Legionella and Coxiella pathogenesis determinants and investigating the contribution of host-pathogen lateral gene transfer in the evolution of pathogenesis systems.
Degtyar, E., T. Zusman, M. Ehrlich and G. Segal. 2009. A Legionella effector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria. Cell. Microbiol. 11:1219-1235.
Rasis, M., and G. Segal. 2009. The LetA-RsmYZ-CsrA regulatory cascade, together with RpoS and PmrA, post-transcriptionally regulates stationary phase activation of Legionella pneumophila Icm/Dot effectors. Mol. Microbiol. 72:995-1010.