Jonathan Gershoni
Cell Research & Immunology
Professor
Tel Aviv University
Israel
Biography
Jonathan Gershoni, Professor, Cell Research & Immunology, Tel Aviv University
Research Interest
A more specific target has been the elucidation of novel neutralizing epitopes of HIV-1. Major questions that motivate our research program are: What constitutes protective immunity and how does one rationally design an effective cross reactive AIDS vaccine? The current focus of the lab is on the immunogenicity of the HIV-1 envelope protein, gp120 and its interactions with the HIV receptor CD4. The experimental strategy consists of high resolution molecular analysis of the epitopes of known cross reactive neutralizing monoclonal antibodies against HIV or systematic analysis of polyclonal sera of HIV infected long term non-progressors. This research has led to more basic studies regarding structural aspect of antigen-antibody recognition, maturation of the humoral immune response as well as autoimmunity in HIV infected individuals.
Publications
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Denisova, G., M. Zerwanizer, D.A. Denisov, E. Spectorman, I. Mondor, Q. Sattentau, J.M. Gershoni 2000 Expansion of epitope cross-reactivity by anti-idiotype modulation of the primary humoral response. Mol. Immunol. 37 :53-58.
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Kantor, R., J.M. Gershoni 1999 Distribution of the CCR5-gene 32 basepair deletion in Israeli ethnic groups. J. AIDS . 20 :81-84.
