Cell Research & Immunology
Tel Aviv University
Tal Pupko, Professor, Cell Research & Immunology, Tel Aviv University
Molecular evolution- studying the evolutionary selective forces shaping genes and genomes and the in-silico predictions of these forces using probabilistic evolutionary models Phylogenetics- reconstructing evolutionary relationships and ancestral sequences, inferring lateral gene transfer, alignment and alignment reliability. Pathogenomics- developing and applying machine-learning tools for predicting effector proteins in pathogenic bacteria such as Legionella and Coxiella. Predicting hydrogenosomal proteins in Trichomonas vaginalis. Functional and evolutionary analysis of HIV-1 genomes. Immunoformatics- predicting B cell epitopes and developing algorithms for analyzing phage display experiments.
Ashkenazy, H., Cohen, O., Pupko, T., and Huchon D. 2014. Indel reliability in indel-based phylogenetic inference. Genome Biol Evol.
Molshanski-Mor, S., Yosef, I., Kiro, R., Edgar, R., Manor, M., Gershovits, M., Laserson, M., Pupko, T., and Qimron, U. 2014. Revealing Bacterial Targets of Growth Inhibitors Encoded by Bacteriophage T7. Proc Natl Acad Sci USA.