Biochemistry
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Alfredo De Biasio

Researcher
Molecular Biology
Elettra-Sincrotrone Trieste
Italy

Biography

Alfredo De Biasio has work focus on the structure and function of DNA sliding clamps and their complexes operating in DNA replication and repair. He is particularly interested in understanding the mechanisms of sliding of the eukaryotic clamp PCNA, and how these mechanisms are modulated by modifications of the PCNA sliding surface, and the implications in DNA damage avoidance. These problems are tackled by an integrative approach that combines X-ray crystallography, NMR and MD simulations.

Research Interest

the structure and function of DNA sliding clamps and their complexes operating in DNA replication and repair. He is particularly interested in understanding the mechanisms of sliding of the eukaryotic clamp PCNA, and how these mechanisms are modulated by modifications of the PCNA sliding surface, and the implications in DNA damage avoidance

Publications

  • Integrative approaches to study the structure and motions of DNA sliding clamps

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