Fabio Mammano
Professor
Biomedical science
IBCN Institute
Italy
Biography
Fabio Mammano is the Director of the CNR Institute of Cell Biology and Neurobiology (IBCN) located in Rome (Italy), Honorary Professor in the Department of Biomedical Science (BMS) at the University of Sheffield (UK) and Visiting Professor at ShanghaiTech University, Shanghai Institute for Advanced Immunochemical Studies (SIAIS). The majority of his research interests focus on sensory and signal transduction in the inner ear and, more recently, encompassed signaling mechanisms in diabetes and cancer.
Research Interest
Cell biology Neuro science Molecular medicine
Publications
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MAMMANO F, FROLENKOV GI, LAGOSTENA L, BELYANTSEVA IA, KURC M, etal (1999). ATP-Induced Ca(2+) release in cochlear outer hair cells: localization of an inositol triphosphate-gated Ca(2+) store to the base of the sensory hair bundle. JOURNAL OF NEUROSCIENCE19: 6918-29.
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BICEGO M, BELTRAMELLO M, MELCHIONDA S, CARELLA M, PIAZZA V, etal (2006). Pathogenic role of the deafness-related the M34T mutation of Cx26. HUMAN MOLECULAR GENETICS 15:2569-2587.
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HERNANDEZ VH, BORTOLOZZI M, PERTEGATO V, BELTRAMELLO M, GIARIN M, etal (2007) Unitary permeability of gap junction channels to second messengers measured by FRET microscopy. NATURE METHODS 4:353-358.
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ANSELMI F, HERNANDEZ VH, CRISPINO G, SEYDEL A, ORTOLANO S, etal (2008) ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca2+ signals across the inner ear. PROC NATL ACAD SCI USA 105: 18770-18775.
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RODRIGUEZ L, SIMEONATO E, SCIMEMI P, ANSELMI F, CALÌ B, etal (2012) Reduced phosphatidylinositol 4,5-bisphosphate synthesis impairs inner ear Ca2+ signaling and high frequency hearing acquisition PROC NATL ACAD SCI USA 109 : 14013-14018.
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CERIANI F, POZZAN T, MAMMANO F (2016) Critical role of ATP-induced ATP release for Ca2+ signaling in non-sensory cell networks of the developing coclea. PROC NATL ACAD SCI USA 113: E7194-E7201.
