Domenico De Rasmo
Researcher
Department ob Biomembranes and Bioenergetics
Institute for Biomembranes and Bioenergetics-CNR
Italy
Biography
"Education and training 2011- today: Researcher at the Institute of Biomembrane and Bioenergetics (IBBE), CNR, Bari. 2011: Specialization degree Summa cum Laude in Clinical Biochemistry - Medicine and Surgery Faculty - University of Bari, Italy. 2008-2011: University Research Fellowship, University of Bari. 2008: Ph.D. in Medical Biology and Biochemistry, University of Bari. Thesis title: “cAMPdependent protein kinase regulates the mitochondrial import of the nuclear encoded NDUFS4 subunit of complex Iâ€. 2005: Master Degree in “Biotecnologie avanzate per diagnosi e terapia molecolare†at CEINGE (genetic engineering centre), Naples, Italy. 2004: Laurea degree in Biological Science (110/110 cum Laude) University of Bari, Italy. Projects and Funds Principal Investigator, Project MIUR, Fondo Investimenti per la Ricerca di Base (FIRB)-Futuro in Ricerca- 2008, “Functional genomics and pathological dysfunctions of redox and bioenergetics cellular systems†(RBFR0813Z5). Participant: Oxidative stress and mitochondrial dysfunctions in Down syndrome “Fondation Jérome Lejeuneâ€. Principal Investigator: Dr. Rosa Anna Vacca Awards 2006: Gold Medal from Italian Society of Biochemistry, 51° National Congress, Riccione , 28-30 Sept. Invited Speaker 2013. Federation of European Biochemical Societies FEBS CONGRESS 2013, July 6th - 11th St. Petersburg, Russia. 2008. 53 ° National Congress Italian Society of Biochemistry, Riccione, Italy. Referee activity He is referee for the following journals: Journal of the Neurological Sciences, Biotechnology Advances, Mitochondrion."
Research Interest
"Regulation of mitochondrial bioenergetics by cAMP signaling and its subcellular compartmentalization in mitochondria. Characterization of molecular mechanism by which the cytosolic and mitochondrial cAMP signaling impacts mitochondrial bioenergetics in mammalian cell cultures and in fibroblast cell cultures from patients with proliferative and neurodegenerative disorders. Molecular mechanisms of cell death. Analysis of the role of intramitochondrial cAMP on the regulation of cellular apoptosis in rat myoblast H9C2 cells. Effects of nutraceutical compounds on mitochondrial biogenesis. Characterization of molecular mechanism of nutraceutical-dependent induction of mitochondrial biogenesis in mammalian cell cultures. "
Publications
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3. De Rasmo D, Signorile A, Santeramo A, Larizza M, Lattanzio P, Capitanio G, Papa S. Intramitochondrial adenylyl cyclase controls the turnover of nuclear-encoded subunits and activity of mammalian complex I of the respiratory chain. Biochim Biophys Acta. 2015 Jan;1853(1):183-91.
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De Filippis B, Valenti D, de Bari L, De Rasmo D, Musto M, Fabbri A, Ricceri L, Fiorentini C, Laviola G, Vacca RA. Mitochondrial free radical overproduction due to respiratory chain impairment in the brain of a mouse model of Rett syndrome: protective effect of CNF1. Free Radic Biol Med. 2015 Jun;83:167-77.
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Cervellati C, Sticozzi C, Romani A, Belmonte G, De Rasmo D, Signorile A, Cervellati F, Milanese C, Mastroberardino PG, Pecorelli A, Savelli V, Forman HJ, Hayek J, Valacchi G. Impaired enzymatic defensive activity, mitochondrial dysfunction and proteasome activation are involved in RTT cell oxidative damage. Biochim Biophys Acta. 2015 Oct;1852 (10 Pt A): 2066-74.
