Eleonora Paradies
Researcher
Department ob Biomembranes and Bioenergetics
Institute for Biomembranes and Bioenergetics-CNR
Italy
Biography
"Education and training B.S. degree in Biological Sciences (cum laude), University of Bari, Italy; 2004. Dissertation: “E. coli expression and functional characterization of two human isoforms of the ornithine mitochondrial transporter and its mutated forms in patients with 3H syndromeâ€; Supervisor: Prof. Ferdinando Palmieri. Formation course for doctoral studies at “CEINGEâ€, University of Naples; July 11, 2005 - Oct. 30, 2005. PhD degree in Biochemical and Pharmacological Sciences, Pharmaco-Biological Department, University of Bari; April 2008. Dissertation: “Study of gene mutations identified in patients affected by HHH Syndrome and by Type 2 Citrullinemia.†Term contract: Pharmaco-Biological Department, University of Bari; May 2008- July 2008. EUMITOCOMBAT project titled “Rational Treatment Strategies Combating Mitochondrial Oxidative Phosphorylation (OXPHOS) Disordersâ€. Fellowship research position: Pharmaco-Biological Department, University of Bari; 2008-2010. Research titled ""Metabolic study of a microorganism producing antibiotic."" Tutor students in Physiology at Faculty of Pharmacy, University of Bari. 2010. ""Researcher"" at the Institute of Biomembrane and Bioenergetics (IBBE), CNR, Bari. 2011-today"
Research Interest
"Mitochondrial transport proteins: purification, reconstitution into liposomes, functional studies. Biochemical and biophysical studies of proteins. Gene expression in E. coli, L. lactis, S. cerevisiae, insect cell line Sf9 and mammalian cells Phenotypical studies in S. cerevisiae Gene Cloning and Site-directed mutagenesis Mitochondrial diseases Good bioinformatics skills particularly with SeqMan, Edit sequence, DNA strider, Prism, Vector NTI."
Publications
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Tessa A., Fiermonte G., Dionisi-Vici C., Paradies E., Baumgartner M.R., Chien Y.H., Loguercio C., de Baulny HO., Nassosgne MC., Schiff M., Deodato F., Parenti G., Rutledge SL., Vilaseca MA., Melone MA., Scarano G., Aldamiz-Echevarria L., Besley G., Walter J., Martinez-Hernandez E., Hernandez JM., Pierri CL., Palmieri F., Santorelli F.M., IDENTIFICATION OF NOVEL MUTATIONS IN THE SLC25A15 GENE IN HYPERORNITHINEMIA-HYPERAMMONEMIA-HOMOCITRULLINURIA (HHH) SYNDROME: A CLINICAL, MOLECULAR, AND FUNCTIONAL STUDY Hum. Mutations 2009 May;30(5):741-8"
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Marobbio C.M., Giannuzzi G, Paradies E., Pierri CL, Palmieri F. “ALPHAISOPROPYLMALATE, A LEUCINE BIOSYNTHESIS INTERMEDIATE IN YEAST, IS TRANSPORTED BY THE MITOCHONDRIAL OXALACETATE CARRIER. “J Biol Chem. 2008 Oct 17; 283(42):28445-53.
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Fiermonte G., Soon D., Chaudhuri A., Paradies, E., Lee P.J., Krywawych S., Palmieri F. and R.H. Lachmann “AN ADULT WITH TYPE II CITRULLINEMIA IN EUROPEâ€.N Engl J Med. 2008 Mar 27; 358(13):1408-9.
