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Loredana Moro

Researcher
Department ob Biomembranes and Bioenergetics
Institute for Biomembranes and Bioenergetics-CNR
Italy

Biography

"EDUCATION AND TRAINING 1995 “Diploma di Laurea” in Biological Sciences (biochemistry and molecular biology orientation) (110/110 cum laude), Faculty of Science, University of Bari, Bari, Italy 1998 “Diploma di Specializzazione” in Biotechnological Applications (50/50 cum laude), Faculty of Science, University of Bari, Bari, Italy 1999-2000 Research training, Department of Pathology, Yale University School of Medicine, New Haven, CT, USA. Field of Study: cell biology/cell signaling 21/03/2003 PhD in Biochemistry and Molecular Biology, Department of Biochemistry and Molecular Biology, Faculty of Science, University of Bari, Italy Field of Study: cell biology/molecular biology/biochemistry PROFESSIONAL EXPERIENCES 12/2001-to date CNR Research Investigator, Institute of Biomembranes and Bioenergetics (IBBE), Bari, Italy 2000-02/2001 Doctoral fellow, Department of Pathology, Yale University School of Medicine, New Haven (CT, USA) 10/2002 Visiting scientist in the Department of Cancer Biology, UMass Medical School, Worcester (MA, USA) 04/2005 Visiting Scientist in the Department of Pathology and Laboratory Medicine, University of Rochester-School of Medicine and Dentistry, Rochester (NY, USA) 12/2005-01/2006 Visiting Scientist in the Department of Pathology and Laboratory Medicine, University of Rochester-School of Medicine and Dentistry, Rochester (NY, USA) 05-06/2006 Visiting Assistant Professor, Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester (NY, USA) 01/2007 Visiting Scientist, Department of Pathology, UT Southwestern Medical Center, Dallas (TX, USA) 01/2007 Nomination as INSERM (Institut National de la Santé et de la recherche médicale, France) Expert for evaluation of projects 03/2008-03/2009 Visiting Assistant Professor, Department of Urology, University of Texas Southwestern Medical Center, Dallas (TX, USA) 05/2010-10/2010 Visiting Assistant Professor, Department of Urology, University of Texas Southwestern Medical Center, Dallas (TX, USA) 11/2010-12/2010 Visiting Assistant Professor, Department of Urology, University of Texas Southwestern Medical Center, Dallas (TX, USA) 01/2012-08/2012 Visiting Scientist, Department of Pathology, NYU Medical Center, New York (NY, USA) Prof. Michele Pagano 10/2012-10/2013 Visiting Scientist, Department of Pathology, NYU Medical Center, New York (NY, USA) Prof. Michele Pagano 09/2014-07/2015 Visiting Scientist, Department of Pathology, NYU Medical Center, New York (NY, USA) Prof. Michele Pagano. HONORS AND GRANTS 1995-1998 Fellowship from the University of Bari to attend the “Scuola di Specializzazione in Applicazioni Biotecnologiche”, Bari, Italy 1999 Fellowship from the CNR to perform a research project (“Role of the 1C integrin in prostate cancer”) at the Department of Pathology, School of Medicine, Yale University (CT, USA) 2003 Co-Investigator, “Regulation of beta1 integrin expression in prostate cancer cells”, AIRC (Italian Association for Cancer Research) grant, Italy 2004-2007 Co-Investigator, “Bioenergetic and apoptotic systems of mitochondria: genomics, proteomics, cellular homeostasis and physiopathology”, MIUR (Ministry of Education, University and Research) grant, Italy 2006 Award “Short-Term Mobility Program 2006” from CNR to perform a research project in the Department of Pathology and Laboratory Medicine, University of Rochester, School of Medicine and Dentistry, Rochester (NY, USA) 2010 Co-PI, DOD grant PC093692 “Suppression of BRCA2 by Mutant Mitochondrial DNA in Prostate Cancer” 2011-2013 PI, Coordinator of the IBBE’s operative unit of the PRIN grant 2009R8LJPS, “Integrin signaling involved in the modulation of invadopodia activity during cancer cell migration and invasion” 2011-2015 PI, Coordinator of the IBBE (Institute of Biomembranes and Bioenergetics, CNR) operative unit for the MERIT Project “Involvement of mitocondrial homeostasis in neoplastic transformation and apoptosis” (RBNE08YFN3_005) 2011-2015 Co-investigator, Ministero dell'Economia e delle Finanze/CNR progetto ""FaReBio di Qualità"" 2015-2017 PI, Project awarded by ""Fondazione Cassa di Risparmio di Puglia"" Title: ""Identificazione di molecole attive per lo sviluppo di nuovi farmaci anti-tumorali contro il carcinoma di prostata"""

Research Interest

"Aimed at understanding the molecular basis of neoplastic transformation and progression with a particular interest to the identification of signaling pathways/molecules selectively activated/inactivated in cancer cells that might represent the target of innovative therapeutic strategies. "

Publications

  • Guaragnella N, Palermo V, Galli A, Moro L, Mazzoni C, Giannattasio S. (2014) The expanding role of yeast in cancer research and diagnosis: insights into the function of the oncosuppressors p53 and BRCA1/2. FEMS Yeast Res 14: 2-16

  • Tsai YS, Lai CL, Lai CH, Chang KH, Wu K, Tseng SF, Fazli L, Gleave M, Xiao G, Gandee L, Sharifi N, Moro L, Tzai TS, Hsieh JT. (2014) The role of homeostatic regulation between tumor suppressor DAB2IP and oncogenic Skp2 in prostate cancer growth. Oncotarget 5: 6425-36

  • Guaragnella N, Marra E, Galli A, Moro L, Giannattasio S. (2014) Silencing of BRCA2 decreases anoikis and its heterologous expression sensitizes yeast cells to acetic acidinduced programmed cell death. Apoptosis 19: 1330-41

  • Guaragnella N, Giannattasio S, Moro L. (2014) Mitochondrial dysfunction in cancer chemoresistance. Biochem Pharmacol 92: 62-72

  • Moro L, Guaragnella N, Giannattasio S. (2015) Silencing of BRCA2 to identify novel BRCA2-regulated biological functions in cultured human cells. J Vis Exp. 2015 Aug 12; 102

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