Petronilli Valeria
Senior researcher
Department of Neuroscience
Institute of Neuroscience Italy
Italy
Biography
"Position: Senior Researcher, Italian National Research Council (CNR), Neuroscience Institute at the Department of Biomedical Sciences, University of Padova, Italy Education: Doctor in Chemistry, University of Padova, Italy, (June 16, 1982) Career: 2003-present: Senior Researcher, CNR Neuroscience Institute 1986-2002: Researcher, CNR 1989-1991: NATO-CNR Senior Fellow, Department of Molecular and Cell Biology, University of California at Berkeley (USA) 1998: Visiting Scientist, Center for Biomedical Imaging Technology, University of Connecticut Health Center, Farmington, Connecticut(USA). 1983-1986: Research Assistant, CNR"
Research Interest
"Study of coupling mechanisms of the reactions of mitochondrial proton pumps to the translocation of protons across the membrane and role of proton electrochemical gradient as energy coupling intermediate between the proton pumps. Electrophysiological investigation of ionic channels in bacterial and mitochondrial membranes by patch-clamp technique. Study of transport mechanisms of ABC transporters by characterization of the bacterial histidine permease and its reconstitution in proteoliposomes. Characterization of the mitochondrial permeability transition pore and study of its involvement in the pathways to programmed and accidental cell death."
Publications
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Giorgio V, Petronilli V, Ghelli A, Carelli V, Rugolo M, Lenaz G, and Bernardi P (2012) The effects of idebenone on mitochondrial bioenergetics. Biochimica et Biophysica Acta-Bioenergetics, 1817, 363-369.
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Porcelli,A.M., Angelin,A., Ghelli,A., Mariani,E., Martinuzzi,A., Carelli,V., Petronilli,V., Bernardi,P., and Rugolo,M. (2009). Respiratory Complex I Dysfunction Due to Mitochondrial DNA Mutations Shifts the Voltage Threshold for Opening of the Permeability Transition Pore toward Resting Levels. Journal of Biological Chemistry, 284, 2045-2052
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Giorgio V, von SS, Antoniel M, Fabbro A, Fogolari F, Forte M, Glick GD, Petronilli V, Zoratti M, Szabo I, Lippe G, and Bernardi P (2013) Dimers of mitochondrial ATP synthase form the permeability transition pore. Proc Natl Acad Sci U S A, 110, 5887-5892
