Botta Bruno
Chemistry and Technology of Drugs
La Sapienza University
Italy
Biography
Bruno Botta was born in 1954 and got his Laurea in Chemistry in 1977 at "Sapienza" University of Rome. During the years 1984-1985, he was appointed as postdoctoral associate at the Department of Chemistry of the University of British Columbia (UBC, Vancouver, Canada) working on the synthesis and biosynthesis of clinically important anticancer alkaloids of the vinblastine-vincristine family. From 1981 to 1992 he was appointed as assistant professor (ricercatore) at the Catholic University of Rome. From 1992 to 2001 he was appointed as associate professor of organic chemistry at "Sapienza" University of Rome (Faculty of Pharmacy) and became full professor at the same University in 2001. Since 2011, he is Head of the Dipartimento di Chimica e Tecnologie del Farmaco and in November 2014 he has been nominated Deputy Provost for the Internationalization of the University of Rome "La Sapienza”. Since March 16 2015, he is Chair of the Cost Action CM-1407 "Challenging organic syntheses inspired by nature - from natural products chemistry to drug discovery". He was invited to give lectures in the following universities: Michigan State University (USA), Wofford College Spartanburg (SC, USA), The Scripps Research Institute, La Jolla (CA, USA), University of British Columbia (Vancouver, Canada), Universidad de Montevideo (Uruguay), Stanford University (CA, USA), Universidade Federal de Pernambuco (Brazil), Toho University, Chiba, Tokyo (Japan). He is author of 150 publications, including 5 patents (3 national and 2 international – USA and Europe), and, beside that, he is author and co-author of 10 books. For the Italian publishing house Edi-Ermes he edited 2 text books of Organic Chemistry.
Research Interest
Pharmaceutical Area
Publications
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Botta B, D'Acquarica I, Nevola L, Sacco F, Lopez ZV, Zappia G, Fraschetti C, Speranza M, Tafi A, Caporuscio F, Letzel MC. Bis (diamido)â€Bridged Basket Resorcin [4] arenes as Enantioselective Receptors for Amino Acids and Amines. European Journal of Organic Chemistry. 2007 Dec 1;2007(36):5995-6002.
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Mascarello A, Mori M, Chiaradia-Delatorre LD, Menegatti AC, Delle Monache F, Ferrari F, Yunes RA, Nunes RJ, Terenzi H, Botta B, Botta M. Discovery of Mycobacterium tuberculosis protein tyrosine phosphatase B (PtpB) inhibitors from natural products. PloS one. 2013 Oct 14;8(10):e77081.
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Botta B, Monache G, Misiti D, Vitali A, Zappia G. Aryltetralin lignans: chemistry, pharmacology and biotransformations. Current medicinal chemistry. 2001 Sep 1;8(11):1363-81.