Bucci Mariarosaria

Biography

1995: Degree in Pharmaceutical Chemistry and Technology 1995: Enabling Pharmacist Profession 1995: First place winner of the School of Pharmacy Specialization at the Faculty of Pharmacy of the University of Naples "Federico II" 1995-1996: Internal student specializing in Experimental Pharmacology at the Department of Experimental Pharmacology at the Faculty of Pharmacy of the University of Naples "Federico II" Oct.-Oct. 99: Ph.D. in Pharmaceutical Sciences XII cycle at the Department of Experimental Pharmacology at the Faculty of Pharmacy of the University of Naples "Federico II" January 2000: Internal student specializing in Experimental Pharmacology (II year) at the Department of Experimental Pharmacology at the Faculty of Pharmacy of Naples University "Federico II" February 2000: Ph.D. in Pharmaceutical Sciences June 2000-June 2002: Research Examination at the Dipter of Pharmaceutical Sciences of the University of Salerno for the project "Mediators of inflammation and atherosclerotic process" November 2002: Sector Researcher BIO / 14 at the Faculty of Pharmacy of the University of Naples "Federico II" at the Department of Experimental Pharmacology. November 2014: Professor Associate sector 05 / G1 in accordance with article 18, paragraph 1, of the Law 240/2010 at the Department of Pharmacy of the University of Naples "Federico II"

Research Interest

The research carried out by Prof. Bucci is essentially based on the study of the physiological processes of the cardiovascular system and of the vascular complications associated with inflammatory diseases. In this research area it is possible to identify the following themes: 1. Study of protease receptors (PAR-1 and PAR-2) as connection point between coagulation and inflammation. In this subject, Dr. Bucci has shown an important role for the PAR-2 ​​receptor in cardiovascular homeostasis. In particular, its role and relationship with TLR-4 in the septic shock was determined. 2. The role of gaseous endogenous mediators (NO, H2S, CO) and their signal transduction pathways in vascular homeostasis and the development of inflammatory-based vascular pathologies. The contribution of Prof. Bucci in this field of research is distributed among the three major gas tachographs in time order. In particular, Dr Bucci was concerned with NO in the first period. An important contribution was to determine the role of caveolina-1, an inhibitory endothelial nitric acid synthase protein (eNOS), in regulating the activity of that enzyme. The subsequent contributions were all aimed at defining the role of L-arginine / NO in the cardiovascular system and in diabetes. As far as CO is concerned, Professor Bucci has recently characterized the ' vasoactive action of donor drugs of CO. H2S research is more complex and extensive. In particular, Prof. Bucci's research work helped define H2S as a non-selective endogenous phosphodiesterase inhibitor. 3. Pharmacological and molecular biology investigations on natural and / or synthesis products such as potential drugs that can be used in therapy such as anti-inflammatory and antithrombinic drugs. In this area, Prof. Bucci has collaborated on studies on the role of sphingosine-1-phosphate and the pathway of the sphingosine-1-phosphate / sphingosine kinase signal as pro-inflammatory signaling in acute inflammation and respiratory tract patterns. In this same field he collaborated in the characterization and definition of mechanisms of action of new synthesis or natural molecules. The study of these mechanisms has been extended and extended through clinical trials on arthritic patients.