Frecentese Francesco

Biography

Born in Naples on 18/01/1980 In service at the Department of Pharmacy since 30 December 2011, as a RTD-B Researcher, Competitive Sector 03 / D1, Scientific Disciplinary Sector CHIM08. He gained national scientific qualification for the second round in the Concertional Sector 03 / D1 at the 2013 Round. TEACHING ACTIVITY Since December 2011, as a winner of a competition at the Department of Pharmacy of the University of Naples Federico II, she has been a researcher in the CHIM / 08 - Chimica Farmaceutica group. For the 2010/2011 academic year, Dr. Frecentese has served as Professor of Pharmaceutical Chemistry for the Master of Biotechnology at the University of Naples "Federico II" in Pharmacy Chemistry. From the academic year 2011-2012 to today, Dr. Francesco Frecentese has served as teaching professor of Pharmaceutical Chemistry for the Master of Biotechnology at the University of Naples Federico II. For the academic year 2011-2012 he has taught the Toxicological Chemistry Analysis - qualitative quantitative analysis methodologies for REACH (Registration, Evaluation, Authorization and Restriction of CHemicals). For the academic year 2012-2013 she has been in charge of the teaching of Analytical Chemistry and Chemical Analysis Laboratory for the Three Year Degree Course in Quality Control. Dr. Frecentese was a thesis lecturer for numerous PhD students in Pharmacy, CTF, Quality Control, Biotechnology of the Farm, Experimental and Compilation Theses, and attended as Master of Pharmacology and CTF Commissions A three-year degree in Quality Control and Master's Degree in Biotechnology of the Medication. MAIN RESEARCH LINES From 2004 until today, Frecentese has focused on research activities related to the design, synthesis and characterization of active molecules on numerous pharmacological targets. Particular attention has been paid to microwave-assisted organic synthesis, to the design and development of serotoninergic heterogeneous ligands, as well as to the synthesis of peptide and peptidomimetic compounds with particular interest in the protease-activated receptors (PARs). Additional interests include the development of new active anthracycline derivatives such as antiretrovirals, peptide molecules and small molecules acting on the sphingosine-1-phosphate pathway and, most recently, the development of new pharmacological tools useful to clarify the biological functions of H2S . International Collaborations  Prof. Fred Naider, Department of Chemistry, Staten Island College, CUNY, New York, USA;  prof. Luiz Juliano, Department of Biophysics, Escola Paulista de Medicina, Federal University of Sao Paulo, SP, Brazil; - Prof. Gilberto de Nucci, Department of Pharmacology, Faculty of Medicine, UNICAMP Campinas SP, Brazil;  Prof. Anna Bielenica, Department of Biochemistry, Medical University of Warsaw, Poland; Dr. Jochen Kuper, Rudolf Virchow Center for Biomedical Research, University of Wuerzburg National Collaborations Professor Paola Massarelli, Department of Medical, Surgical and Neuroscience Sciences University of Siena,  Prof. Lucio Annunziato, Department of Neuroscience, Reproductive and Odontostomatology Sciences, University of Naples Federico II, no. 3 publications  Prof. Alfredo Budillon, Experimental Pharmacology Unit, National Institute of Tumors Foundation "G. Pascale ", - Prof. Barbara Gatto, Department of Medicine Sciences, University of Padua, No.1 publication - Prof. Vincenzo Calderone, Department of Pharmacy, University of Pisa PARTICIPATION OR DIRECTION TO NATIONAL SCIENTIFIC RESEARCH PROJECTS, SUBMITTED FOR FINANCING ON THE BASIS OF COMPETITIVE BANDS WHICH PREVENT THE REVISION BETWEEN PARTIES Dr. Francesco Frecentese has participated or is still participating in the following national scientific research projects, which are eligible for funding on the basis of competitive calls for peer review: - FIRB annuality 2013 project entitled "Developing drugs that activate or selectively inhibit the Na + / Ca2 + heat exchanger isoforms to improve learning and memory deficits "- RESPONSIBLE Unit - Project PON03PE_00146_1 - BIOFAR - PARTICIPANT to the Research Program - PRIN annuality project 2010/2011 titled" Role of transduction path L -cysteine ​​/ H2S in inflammatory pathologies: identification of a new therapeutic target "- PARTICIPANTS to the Research Program; - Regional Law Project No. 5 of 28.03.2002 - Annual Report 2005 titled "Summary of New Serotonergic Receptor Ligands and Evaluation of Antitumor Activity in Prostate Cancer" - PARTICIPANT in the Research Program; ACTIVITY OF REFERENCE Dr. Frecentese is referring to the following journals: - Journal of Medicinal Chemistry - Letters in Organic Chemistry - Bioorganic & Medicinal Chemistry Letters

Research Interest

rom 2004 until today, Frecentese has focused on research activities related to the design, synthesis and characterization of active molecules on numerous pharmacological targets. Particular attention has been paid to microwave-assisted organic synthesis, to the design and development of serotoninergic heterogeneous ligands, as well as to the synthesis of peptide and peptidomimetic compounds with particular interest in the protease-activated receptors (PARs). Additional interests include the development of new active anthracycline derivatives such as antiretrovirals, peptide molecules and small molecules acting on the sphingosine-1-phosphate pathway and, most recently, the development of new pharmacological tools useful to clarify the biological functions of H2S .