Grumetto Lucia

Biography

987 - Degree in Biological Sciences, 110 and Praise - University of Naples. Thesis in Biological Chemistry. - 1996 - Degree in Pharmacy, 110 and Praise - University of Naples. Experimental Thesis in Pharmaceutical and Toxicology Chemistry. - 29 September 1986-30 June 1988: Technical Agent at the Institute of Ophthalmology - II Faculty of Medicine and Surgery - University of Naples; - July 1, 1988 - February 28, 1991: Technical Officer VIII functional qualification at the Department of Organic and Biological Chemistry at the University of Naples, responsible for analysis service. - March 1991 - May 2002: Technical Officer VIII functional qualification at the Department of Pharmaceutical and Toxicology Chemistry of the University of Naples. - June 2002 to date: researcher Confirmed in the disciplinary field CHIM 08 - From the academic year 2005/06 to today: Professor Aggregato as per art.1, comma 11 of the law 230/2005. - Has performed the following teaching assignments: Analysis of Medicaments (aa.aa. 2003/04, 2004/05, 2005/06, 2006/07, 2007/08, 2008/09, 2009/2010 (Graduate of Quality Control - University of Naples Federico II) Pharmaceutical chemistry (aa.aa. 2010/2011, 2011-2012, 2012-2013 - graduate course Medical-Scientific Informant - Second University of Naples). Toxicological Chemistry (aa 2011/2012 - Graduate Degree in Quality Control - University of Naples Federico II) Food legislation and quality control legislation in the food sector (2012-2013 until today - Graduate degree in Quality Control - University of Naples Federico II)

Research Interest

Dr. Lucia Grumetto's scientific activity has taken place and takes place in those fields of research pharmaceutical companies that use the analytical methodologies devoted to it, such as high performance liquid chromatography, gas chromatography, spectrometry and spectrophotometry. THE Scientific work derived from the use of such methods includes the search for drugs, xenobios and impurities, even traces, in complex, organic, pharmaceutical, and nutritional matrices in theses studies determine the degree of purity of pharmaceutical formulations, the possibility of contamination of foods for migration from containers, the degree of absorption of environmental contaminants by particular bands of population. Beyond such immediate applications, the chromatographic methods were applied to acquire interaction data with particular stationary phases simulating biological structures relevant for pharmacokinetic purposes (biochromatography). Within such studies, they also faced on physical chemical bases, the problem of bioavailability, controlled drug release, and optimization of pharmacokinetic properties. Bio-chromatographic studies on seroproteins immobilized and immobilized phospholipids, in fact, have allowed to clarify the characteristics structural of drugs regulating interactions with such biophases. Thanks to these studies, they have, among other things, Proposed "in vitro" models for evaluation on a rational basis and from the early stages of development salient pharmacokinetic characteristics of a drug such as drug-protein binding, bioavailability and ability to arrive in particular districts such as the central nervous system.