Irace Carlo

Biography

Carlo Irace was born in Naples on 22/12/1972. In 2000 he earned a degree in Pharmaceutical Chemistry and Pharmacy Technology at the Pharmacy Faculty of the University of Naples "Federico II". From March 1997 to October 2000 he attended the Department of Natural Resources Chemistry at the University of Naples "Federico II" as an internal student, where he was in the 1998 and 1999 years holding a contract of technical-scientific collaboration. His research activity, aimed at the preparation of the Experimental Thesis, concerned the structural characterization and study of the bioactivity of secondary metabolites isolated from benthic marine organisms. Since November 2000 he has been carrying out his research activity at the Department of Experimental Pharmacology at the University of Naples "Federico II". His scientific interest has focused on the study of molecular mechanisms regulating iron cell homeostasis, the study of the proteins involved in such regulation, and the implication of this metal in inducing oxidative stress and degenerative processes. In December 2003 he received his Ph.D. degree in Medicine Science by discussing a thesis entitled "Transcriptional and post-transcriptional regulation of ferritin: modulation by oxalomalate". In 2004 he was the holder of a research contract at the Department of Experimental Pharmacology and in 2005 he was the winner of a Research Certificate at the Regional Expertise Center in Molecular Diagnostics and Pharmacology (CRDC "DFM"). In 2006 he was the winner of the competition for a place as a researcher at the Faculty of Pharmacy (R / 04/2005), disciplinary sector BIO / 10 (BIOCHEMISTRY). By decree 924 of 28/02/2006, since March 1, 2006 he is a university researcher for the BIO10 (Biochemistry) department in charge at the Department of Pharmacy, achieving in 2009 the confirmation of the role of university researchers. He is currently a professor of "Biochemistry" and "Applied Biochemistry" at the CdS in Pharmacy, "Physiology and Biochemistry of Skin and Appendices" His current research areas are focused on the realization and optimization of in vitro and in vivo experimental models in iron metabolism studies and on the effect of xenobiotics in regulating proliferation / cell differentiation processes. Scientific activity is documented by numerous scientific articles published extensively in widely published international journals, cited in the Journal Citation Index (JCI), and its research has been supported by numerous grants as part of the operating unit (2000 , 2002, 2003, 2004, 2006, 2007, 2008 and 2011) and unit manager (2013, 2015). Since March 31, 2017, the National Scientific Research Institute (ASN) has been in possession of a professor of competition for the competition sector 05 / E1 (Article 16, paragraph 1, Law 240/10).

Research Interest

The main scientific and research areas of Dr. Carlo Irace and the Biochemistry Research Group (BioChem) at the Department of Pharmacy are focused on the design and optimization of experimental models in vitro and in vivo for: i) the study of the regulation of iron metabolism in different physiopathological conditions; ii) the realization of bioscreens in the preclinical evaluation of the biological activity of molecules of various origin; iii) preclinical development of new nanoviruses, teranostatic systems, and new cancer therapy drugs. More generally, the BioChem Group is interested in multidisciplinary research projects focusing on the study of biochemical and bio-molecular mechanisms in human pathologies and drug response. Numerous publications and extensive scientific production document this biomedical research activity. In particular, the main fields of experience and the latest research lines have been developed on the following points: - Analysis of expression of ferritin, transcriptor receptor, and other major proteins involved in the maintenance of iron cell homeostasis; - Study of regulating RNA binding and expression of Iron Regulatory Proteins (IRPs) by endogenous and exogenous factors; - Evaluation of the cytoprotective role and the antioxidant effect of ferritin in different cell types and in various physiopathological conditions; - Study of the regulation of iron metabolism in different physiopathological conditions and implications for cell survival; - Iron Homeostasis in DNA-infected mammalian cells: implications for virus / host interaction. - Study of the effect of environmental contaminants on marital metabolism and implications for regulation of cell proliferation / differentiation processes; - Preclinical evaluation in in vitro and in vivo experimental models of the biological activity of naturally occurring substances of various origin; - Pre-clinical development of new molecules as anti-proliferative agents for cancer therapy. In recent years, Dr. Irace has been engaged - as a manager or component of an operational unit - in multidisciplinary research projects aimed at the development of new nanoviruses and teranostic systems capable of targeting specific target cells of alternative metal-based drugs of transition, as low molecular weight complexes of ruthenium with antiproliferative action.