Lavecchia Antonio

Biography

Degree in Pharmacy on November 5, 1992 with 110/110 praise and praise at the University of Pisa. Master in "Management Development" on May 20, 1994, at the Management School of the Free International University of Social Studies (LUISS) in Rome. Ph.D. in Pharmaceutical Sciences on April 28, 1999, at the University of Catania . During his PhD, he held a period of scientific training at the University of Salerno, working with the Proff. E. Novellino and G. Greco. A one-year scholarship in 1999, aimed at the design and synthesis of new anticancer chemotherapeutic drugs at the Department of Pharmaceutical Sciences at the University of Salerno. Visiting Scientist at the Department of Medicinal Chemistry at the College of Pharmacy of the University of Minnesota, USA, working with the Proff. Philip Portoghese and David Ferguson (1998-1999). Researcher in Pharmaceutical Chemistry in 2001, at the University of Naples "Federico II". Visiting Scientist at Barcelona Institute of Recerca Hospital ( IMIM ), working with Prof. Ferran Sanz (2001). Associate Professor of Pharmaceutical Chemistry in 2005. Visiting Scientist at the Institut für Organische Chemie und Biochemie - Technische Universität, Munich (Germany), working with Prof. Horst Kessler (2002). Visiting Scientist at the Rega Institute for Medical Research , Katholieke Universiteit Leuven (Belgium), working with Prof. Jan Balzarini (2008). Current Position: Ordinary Professor of Pharmaceutical Chemistry at the Department of Pharmacy of the University of Naples Federico II.

Research Interest

virtual screening based on ligands and structures of biological targets ( ligand- and structure-based virtual screening); - machine learning techniques ; - polypharmacological approaches in silica ; - homology modeling; - QSAR of 3D-QSAR; - development of pharmacophore models; - Molecular docking strategies ; - ab initio methods ; - Classical Molecular Dynamics (MD) simulations, combined with computational methods based on the integration of classical mechanics with quantum chemistry (eg QM / MM simulations), and coupled with advanced techniques for the calculation of free energy.