Roviezzo Fiorentina

Biography

October 1997: Degree in Chemistry and Pharmaceutical Technologies November 1998 : Enabling Pharmacist Profession May '98: "Paola Persico" Award for Best Experimental Thesis in Pharmacology of the Year 1997 Oct.'98-Oct.'01: Ph.D. in Pharmaceutical Sciences at the Department of Experimental Pharmacology at the Faculty of Pharmacy of the University of Naples "Federico II" February 2002: Ph.D. in Pharmaceutical Sciences Gen.'03-to Gen 05: Post-doctoral research at the Department of Pharmaceutical Sciences of the University of Salerno Gen 05-Jan 06 Research bursary at the Department of Experimental Pharmacology at the Faculty of Pharmacy of the University of Naples " Federico II " June 05 Winner of the" Farmindustry Award for Pharmacological Research "for the work" Human eosinophil chemotaxis and selective in vivo recruitment by sphingosine 1-phosphate "Proc Natl Acad Sci USA 2004, 101: 11170-11175. Marz 06 BIO / 14 Sector Researcher at the Faculty of Pharmacy of the University of Naples "Federico II" at the Department of Experimental Pharmacology . June 07 Winner of "Farming Industry Award for Pharmacological Research" for Work "Sphingosine-1-phosphate / Sphingosine Kinase Pathway is Involved in Mouse Airway Hyper-responsiveness. Am J Respir Cell Mol Biol. Feb 22, 2007 Permanent at Foreign Research Institutes Jun.'00-Sep.'01: Department of Biochemical Pharmacology, William Harvey Research Institute, Queen Mary University of London, UK, Tutor Prof. Mauro Perretti Dr. Roviezzo is a member of the Italian Society of Pharmacology (SIF) and European Respiratory Society

Research Interest

The research activity focuses on the study of the mechanisms underlying the development and resolution of the inflammatory response. In particular, the molecular mechanisms underlying the production of nitric oxide and its role as inflammatory mediator were studied. This study focused mainly on the role of the NO Synthetase (NOS) endothelial form. Nitrogen oxide production by NOS is subject to a complex regulation system. In basal condition, this enzyme releases very small amounts of NO, but when stimulated, a significant increase in its production is observed. In this context particular attention has been paid to the role of sphingolipids in eNOS regulation, and to the actions mediated by sphingosine-1-phosphate (S1P). S1P represents the symbol of a new class of bioactive molecules involved in many pathophysiological processes. The role of S1P has been intensively studied in recent years, and it has become clear that S1P is involved in biological mechanisms such as cell growth and survival, differentiation, calcium homeostasis and many signal pathways involved in smooth muscle contraction. The fact that S1P was accumulated in mast cells led to hypothesis of its involvement in the pathophysiology of asthma and air permeability. The role of S1P in asthma has also been confirmed by the finding of high levels of S1P in the BAL of asthmatic subjects. Dr. Roviezzo published data related to the chemotherapy capacity of S1P against eosinophils in vivo and in vitro. Currently Dr. Roviezzo has turned his attention to aerobic inflammatory pathologies such as asthma and COPD. In recent years, this research has led him to accumulate data on the role of S1P on the regulation of bronchial tone in physiological and pathological conditions, showing that the role of S1P appears to be decisive in pathological conditions such as those that reoccur in sustained inflammation to allergize. These data are in line with the data in the literature suggesting a direct involvement of S1P in bronchial hyperactivity. In recent years, this research has led him to accumulate data on the role of S1P on the regulation of bronchial tone in physiological and pathological conditions, showing that the role of S1P appears to be decisive in pathological conditions such as those that reoccur in sustained inflammation to allergize. These data are in line with the data in the literature suggesting a direct involvement of S1P in bronchial hyperactivity. In recent years, this research has led him to accumulate data on the role of S1P on the regulation of bronchial tone in physiological and pathological conditions, showing that the role of S1P appears to be decisive in pathological conditions such as those that reoccur in sustained inflammation to allergize. These data are in line with the data in the literature suggesting a direct involvement of S1P in bronchial hyperactivity.