Sepe Valentina

Biography

Dr. Sepe was born on 06/03/1978 She has been in service at the Department of Pharmacy since 17 December 2010 Role University Researcher Competitive Sector 03 / C1-Organic Chemistry Disciplinary Scientific Sector CHIM / 06 Enabled for the Conical Sector 03 / C1 - Organic Chemistry-Second Band Information on the scientific path -Military science in 1996 with the vote of 60/60 -Laurea in Pharmaceutical Chemistry and Technology at the Faculty of Pharmacy on 26.10.2001, vote 110/110 with praise. Experimental Thesis in Organic Chemistry titled "Isolation and Structural Determination of a New Plakortis Simplex Carbonic Opanoid " Speaker Prof. Ernesto Fattorusso. - PhD - November 2001 , winner of the Ph.D. admission competition in "Medicine Science - 17th cycle of three years" at the Faculty of Pharmacy of the University of Naples. -14 December 2004 , Exam for the Ph.D. in Pharmacology Science Doctorate by submitting a final dissertation titled: "Structural and synthetic studies on Sfinxolids, potent cytotoxins of marine origin to antimicrobial activity", tutor Maria Valeria D ' Auria - Session 2002 : Enabling Pharmacist Profession . - From March 1, 2014 to August 31, 2014 Research at the Department of Drug Design and Pharmacology, Faculty of Medicine and Medical Science, University of Copenhagen Academic positions - In 2010 he was awarded the winner of the University Researcher , CHIM06-CHEMICAL ORGANIC Disciplinary Sector , and from 17-12-2010 to date he is a researcher at the Department of Pharmacy. Responsibility of studies and scientific research entrusted by qualified public or private institutions - Responsibility for scientific research entrusted by the Department of Natural Resources Chemistry of the University of Naples "Federico II". Scientific collaboration agreement on the subject "Isolation and structural determination of metabolites of cytotoxic activity from tunicates of the Mediterranean and porphiles". from 01-12-2001 to 30-03-2002 - 4-month scholarship at the Department of Natural Resources Chemistry of the University of Naples "Federico II" under the feasibility study "Study-project on Callipeltina A: mechanism of action and identification of the molecular portions responsible for anti-HIV activity and heart rate adjustment ", funded by the Campania Region (POR 2000-2006, Measure 3.13, FSE Fund). Project holder: Prof. Maria Valeria D'Auria. from 01-04-2005 to 31-07-2005 - A 12-month scholarship for the project "Higher Education in Advanced Biology and its Applications: Creating Professional Profiles in the Fields of Diagnostics and Molecular Pharmacy" under the 2006 POR, conducted at the Center of Regional Competence in Molecular Diagnostics and Pharmacology. from 22-05-2006 to 21-05-2007 - Research grant for research activities under the project "Biodiversity and the Marines Actives of Coral Reef Initiative in the South Pacific" CRISP, IRD-AFD Convention CZZ3012-02 U. Research topic "Insulation and structural characterization of marine metabolites "for research carried out at the Department of Chemistry of Natural Substances of the Faculty of Pharmacy of the University of Naples" Federico II ". from 01-03-2008 to 31-08-2008 - Research grant for research activities under the "CRISP", IRD-AFD Convention CZZ3012-02U on the topic "Isolation and structural characterization of new metabolites from sponges collected in the South Pacific "for research activities carried out at the Department of Chemistry of Natural Substances of the Faculty of Pharmacy of the University of Naples" Federico II ". from 02-04-2009 to 30-09-2009 - Responsibility of laboratory activity in the BAR Pharmaceuticals Convention with the Pharmacy Department. Prot. 2014/0031199 del 04/04/2014. Title of the Convention "Lead the synthesis of bile acid derivatives". Research Manager: Prof. Angela Zampella. Duration of the agreement: 24 months. from 04-04-2014 to 03-04-2016 - Responsibility of laboratory activity in the BAR Pharmaceuticals Convention with the Pharmacy Department. Prot. 2016/003153 of 14/01/2016. Title of the Convention "Development of active molecules on metabolic nuclear receptors". Research Manager: Prof. Angela Zampella. Duration of the agreement: 24 months. from 14-01-2016 to today Academic activity. Teachings: - Organic Chemistry for the Degree Course in Scientific Information on Medication and Diagnostic Products ( 6 CFU , 48-hour module) for academic years 2011-2012, 2012-2013 and 2013-2014. - General Chemistry for the Degree in Herbal Sciences ( 5 CFU , module 40 hours) for academic years 2014/2015 and 2016/2017. -The dott. Sepe has collaborated, through the exercises and the participation in the exam commissions, for conducting the Organic Chemistry I course for the CTF degree course. He is currently collaborating through the exercises and participation in the examination commissions, at the completion of the Physical Methods in Organic Chemistry course for the CTF degree course. Participation in Courses : -XXIX Summer Course "A. Corbella "Organic Chemistry Synthesis Seminars, Palazzo Feltrinelli of the University of Milan, Gargnano (Bs), June 2004. During this course she availed of a scholarship that gave her the opportunity to hold oral communication from title "C23-C35 portion of reidispongiolide A: determination of relative and absolute configuration and enantioselective synthesis" . -XXX Summer Course "A. Corbella "Organic Chemistry Synthesis Seminars, Palazzo Feltrinelli of the University of Milan, Gargnano (Bs), June 2005. -XXXI Summer Course" A. Corbella "Organic Chemistry Synthesis Seminars, Palazzo Feltrinelli of the University of Milan, Gargnano (Bs), June 2006. Also for the 2006 edition co-authored the review entitled " Critical Survey covering the Year 2005: Total Synthesis of natural products ". PhD Thesis in Scientific Information on Drug and Diagnostic Products, Pharmacy, and Pharmaceutical Chemistry and Technology (CTF). In the course of the tutorial activities, he attended many students during their experimental theses, instructing them to learn basic laboratory techniques, modern chromatographic and spectroscopic techniques, and collaborating in the elaboration of theses. During his career, Dr. Sepe was a graduate thesis lecturer for undergraduate students in Scientific Information on Drug and Diagnostic Products, Chemistry and Pharmaceutical Technologies, Pharmacy. Dissertation Thesis Writer: Claudia Finamore. Doctoral Program : Medicine Science, XXIX. Final elaborated title: Semisynthetic bile acid derivatives as human receptor modulators . Participation as a speaker at conferences and conferences of national / international interest Dr. Sepe presented the results of the scientific activity carried out during his career at numerous congresses / conferences. The following are the oral communications presented at national and international conferences. 1. V. Sepe, C. D'Amore, FS Leva, B. Renga, MV D'Auria, V. Limongelli, S. Fiorucci, A. Zampella. "Potent dual agonists of nuclear and membrane bile acid receptors". XXV National Congress of the Italian Chemical Society. Arcavacata di Rende, (CS), 2014 , 8-12 September, Oral Communication 2. MV D'Auria, A. Zampella, V. Sepe. "Synthetic studies on Perthamide C", XXXIII National Conference of the Organic Chemistry Division of the Italian Chemical Society. San Benedetto del Tronto (AP), 2010 , September 12-16, Flash Communication 3. XXIX Summer Course "A. Corbella "Organic Chemistry Synthesis Seminars, Palazzo Feltrinelli of the University of Milan, Gargnano (Bs), June 2004. During this course she availed of a scholarship that gave her the opportunity to hold oral communication from title "C23-C35 portion of reidispongiolide A: determination of relative and absolute configuration and enantioselective synthesis" . Organization of scientific conferences Member of the International Summer School of Natural Products ( ISSNP ) for the first and second editions (6-10 July 2015 and 3-7 July 2017 respectively). Participation in national and international research projects - Participation as a PhD in Research at the activities of the University of Naples "Federico II" as part of the PRIN 2003 project . Scientific Coordinator: Ernesto Fattorusso Research Title: NATURAL SUBSTANCES AND SYNTHETIC MATERIALS WITH ANTITUMORAL ACTIVITY. Code 2003039581 from 20-11-2003 to 19-11-2005 -Participation as a scholarship to the research group of prof. Maria Valeria D'Auria, scientific director of POR Campania 2000-2006 project . Research Title: Study-Project on Callipeltina A: Mechanism of action and identification of molecular portions responsible for anti-HIV activity and cardiac rhythm adjustments. ESF Fund (Letter of appointment n ° 0157549 of 22/2/2005) from 22-05-2005 to 31-10-2006 -Participation as a Fellowship at the CRISP 2006-2008 Research Unit C2 . Scientific Responsible Maria Valeria D'Auria. Research title: Biodiversity and the Marines Actives of the Coral Reef Initiative in the South Pacific CRISP, IRD-AFD Convention CZZ3012-02 U. from 01-01-2006 to 31-12-2008 -Participation as a fellow student at the activities of the unit of Naples University "Federico II" under the PRIN 2007 project . Scientific Coordinator: Ernesto Fattorusso; replaced by prof. Raffaele Riccio. Research Title: NATURAL SUBSTANCES AND SYNTHETIC MATERIALS WITH ANTITUMORAL ACTIVITY. Code 2007KZ9W5J. from 22-09-2008 to 21-09-2010 -Participation in the FP7-KBBE-2009-3-245137 project MAREX : Exploring Marine Resources for Bioactive Compounds: From Discovery to Sustainable Production and Industrial Applications 2010-2014. Available 2016 at http://www.marex.fi/participants/90-universita-de-napoli.html from 01-01-2010 to 31-12-2014

Research Interest

The doctorate has done full-time research at the Department of Natural Resources Chemistry, at the Department of Pharmacy at the University of Naples "Federico II". The first part of the scientific activity is the natural continuation of a research line carried out by the group of prof. Maria Valeria D'Auria, where she joined in 2002 with the beginning of PhD research. The research activity is focused on topics of Organic Chemistry. In particular it can be divided into two main themes: isolation of secondary metabolites from porphyrins - stereochemical and synthetic studios. In the first phase, Dr. Sepe has devoted himself to the study of pharmacologically active secondary metabolites isolated from marine organisms such as echinoderms and porphyria. Numerous marine invertebrate species of different geographic origin have been analyzed and isolated dozens of compounds isolated, many of them with unprecedented structural architectures in literature and promising pharmacological properties. At the same time, he focused on synthetic issues aimed at resolving stereochemical issues. The research carried out at this stage allowed the resolution of specific issues, but it was also the right gym for the research activity of the last period. The skills gained in the field of organic synthesis have created a new line of research, with remarkable resonance on the international scene. The biochemistry study of marine organisms was dealt with in a profoundly different perspective from the initial stage. It has shifted from " high-throughput screening " of marine organisms to " target-oriented discovery " focused on identifying marine natural products as nuclear receptor ligands. Isolation, biochemical characterization, derivative design accompanied by total synthesis work as well as in vitro and in vivo pharmacological testing has led to the identification of a wide range of modulators such as potential lead for ulcerative colitis and cholestasis therapy. Currently Dr. Sepe's research is about the synthesis of new lead compounds, promising for therapy of pathologies such as metabolic syndrome, diabetes, NASH, PBC.