Del Porto Paola
Researcher
Department of Biology and biotechnology
University La Sapienza
Italy
Biography
1987 Degree in Biological Sciences (110 and Praise) 1989 Enrollment to the profession of Biologist 1993 Doctorate in Experimental Medicine Research
Research Interest
-Structural and functional characterization of human ï§/ï¤ T lymphocytes (Mami-Chouaib F. 1990 J. Exp. Med.; Del Porto P. 1991 J. Exp. Med.; Mami-Chouaib F. 1991 J. Immunol. Del Porto P. 1994 J. Immunol.). -Development of human thymocytes (Del Porto P. 1995 Proc. Natl. Acad. Sci. USA) -Host-pathogen interactions in HCV infection. Identification of: i) viral immunogenic determinants for human T lymphocytes, ii) immunological and viral correlates of spontaneous elimination of the virus, iii) mechanisms of viral escape from B and T cell responses in Hepatitis C virus infection (Del Porto P., J. Immunol. 1999; Del Porto P., Virology, 2000; Frasca L., Hepatology 2003; Spada E., Gut 2004; Guglietta S., Eur J Immunol 2005; Folgori A., Gut 2006; Scottà C., J. Hepatol. 2008; Guglietta S., Virology 2009; Spada E., Clin Infect Dis in press). -Host pathogen interaction in Toxoplasma gondii infection. Identification of: i) T. gondii immunogenic determinants for human T and B cells ii) vaccine candidates iii) mechanisms of immunosuppression by the parasite. (Del Porto P. Microbes Infect. 2004; Beghetto E., J Infect Dis. 2005; Guglietta S. Microbes Infect 2007; Rosenberg C. Vaccine 2009; D’Angelillo A. Apoptosis 2011). - Analysis of the role of CFTR in macrophage functions. (Del Porto P PlosOne 2011).
Publications
-
Del Porto P, Cifani N, Guarnieri S, Di Domenico EG, Mariggio MA, Spadaro F, Guglietta S, Anile M, Venuta F, Quattrucci S, Ascenzioni F. Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa. PloS one. 2011 May 18;6(5):e19970.
-
Franceschini D, Del Porto P, Piconese S, Trella E, Accapezzato D, Paroli M, Morrone S, Piccolella E, Spada E, Mele A, Sidney J. Polyfunctional type-1,-2, and-17 CD8+ T cell responses to apoptotic self-antigens correlate with the chronic evolution of hepatitis C virus infection. PLoS pathogens. 2012 Jun 21;8(6):e1002759.
-
Mannironi C, Camon J, De Vito F, Biundo A, De Stefano ME, Persiconi I, Bozzoni I, Fragapane P, Mele A, Presutti C. Acute stress alters amygdala microRNA miR-135a and miR-124 expression: inferences for corticosteroid dependent stress response. PLoS One. 2013 Sep 4;8(9):e73385.
