Prosseda Gianni
Researcher
Department of Biology and biotechnology
University La Sapienza
Italy
Biography
He is a researcher at University of Rome (Sapienza), Italy. Dr. Prosseda's research activity has always been centered on the study of gene expression in bacteria.
Research Interest
Dr. Prosseda's research activity has always been centered on the study of gene expression in bacteria. In particular, in the past, significant results were obtained in the study of the regulation of virulence genes in Shigella. Recently, a research line has been initiated on the molecular mechanisms underlying the evolution of pathogenic E.coli , leading to the characterization of major pathoadaptative mutations responsible for the increase of pathogenic potential on enteroinvasive E.coli and Shigellastrains. One of these involves the speG gene and allowed to characterize the role of polyamines, specifically the spermidine, in the virulence system of Shigella. Another recent research line is directed to the identification and characterization of new molecules with antimicrobial activity.
Publications
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Prosseda G, Mazzola A, Di Martino ML, Tielker D, Micheli G, Colonna B. A temperature-induced narrow DNA curvature range sustains the maximum activity of a bacterial promoter in vitro. Biochemistry. 2010 Mar 10;49(13):2778-85.
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Giangrossi M, Prosseda G, Tran CN, Brandi A, Colonna B, Falconi M. A novel antisense RNA regulates at transcriptional level the virulence gene icsA of Shigella flexneri. Nucleic acids research. 2010 Feb 3;38(10):3362-75.
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Casalino M, Prosseda G, Barbagallo M, Iacobino A, Ceccarini P, Latella MC, Nicoletti M, Column B. Interference of the CadC regulator in the arginine-dependent acid resistance system of Shigella and enteroinvasive E. coli. Int J Med Microbiol. 2010 Jun; 300 (5): 289-95. doi: 10.1016 / j.ijmm.2009.10.008. Epub 2009 Dec 2. PubMed PMID: 19959396.
