Saggio Isabella
Associate professor
Department of Biology and biotechnology
University La Sapienza
Italy
Biography
2016, Selected member of the School of advanced studies at Sapienza University (SSAS) 2015, 2016: Visiting scientist Nanyang Technological University (NTU), Singapore, Telomere lab directed by D. Rhodes. Promoter NTU-Sapienza 5year cooperation agreement. 2011 to date: Founder, coordinator and teacher of the Double Degree between Sapienza University and the Universities Paris5 and Paris7. The first international degree in Genetics and Molecular Biology at Sapienza University of Rome, which includes teaching courses held in in English, in Italy and in France, open to both Italian and French students. 2010: Visiting scientist (CNR financed) Paris 7 University and Pasteur Institute (France), Immunology lab directed by A. Cumano. 2008: Visiting scientist (CNR financed) Salk Institute (La Jolla CA USA), Virology and Gene Therapy lab directed by I. Verma. 2008-to date: Teaching member of the PhD school in Genetics and Molecular Biology, Sapienza University of Rome. 2005-to date: Associate Professor of Genetics and Gene Therapy. Group leader (see web-site www.saggiolab.com (link is external)), Dept of Biology and Biotechnology Charles Darwin, Sapienza University of Rome. Founder and Director, Master in Life sciences communication, Sapienza University (see website www.mastersgp.it (link is external)). Erasmus project coordinator Sapienza University /University of Paris 5 and 7. 2004: Visiting scientist (CNRS financed) Lyon Laennec University, Lyon France. Virology lab directed by P. Boulanger. 2003 to date: Selected associate scientist IBPM research institute, CNR 2003-2010: Associate scientist and group leader San Raffaele Science Park Rome 1996-2003: Assistant Professor, Dept of Genetics and Mol. Biology Sapienza University of Rome Italy. 1995-96: EU postdoctoral fellow, Oncogenic Virus Lab, Gustave Roussy Institute, Paris France. 1991-94: PhD fellow at IRBM Merck research institute directed by R. Cortese, Rome Italy. 1989-90: Research fellow, Laboratory of Virology National Health Institute, Rome Italy. 1988: Laurea full marks cum laude, Dept of Genetics and Mol. Biology, Sapienza University of Rome Italy.
Research Interest
Viral vectors and gene therapy We study biological interactions occurring between viruses and the host cell, by single gene, single pathway and high throughput analysis, to understand the toxicity of viral vectors used in gene therapy and to clarify viral and cellular pathways. Stem cells and ageing We’re interested in in vitro and mouse models of human diseases, for their study and for designing therapeutic strategies, with specific focus on genes/diseases related with telomeres, mesenchymal stem cells and ageing.
Publications
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Piersanti S, Burla R, Licursi V, Brito C, La Torre M, Alves PM, Simao D, Mottini C, Salinas S, Negri R, Tagliafico E. Transcriptional response of human neurospheres to helper-dependent CAV-2 vectors involves the modulation of DNA damage response, microtubule and centromere gene groups. PloS one. 2015 Jul 24;10(7):e0133607.
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Sacchetti B, Funari A, Remoli C, Giannicola G, Kogler G, Liedtke S, Cossu G, Serafini M, Sampaolesi M, Tagliafico E, Tenedini E. No identical “mesenchymal stem cells†at different times and sites: human committed progenitors of distinct origin and differentiation potential are incorporated as adventitial cells in microvessels. Stem cell reports. 2016 Jun 14;6(6):897-913.
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Burla R, La Torre M, Saggio I. Mammalian telomeres and their partnership with lamins. Nucleus. 2016 Apr 25;7(2):187-202.
