Sorrentino Rosa
Ordinary Professor
Department of Biology and biotechnology
University La Sapienza
Italy
Biography
Education and training High school degree: 1969 Classic Lycee Degree BsC: Year: 1973 Field of Study: Pathology 110/110 cum laude Specialization School: 1977 Field of Study: Microbiology 70/70 cum laude Fellowships and Training: 1975-77: Laboratory of Cell Biology, CNR, Rome, Italy: Cell Biology; 1977-8: Paterson Laboratories, Christie Hospital and Holt Radium Institute in Manchester (England): Cell Biology 1981 EMBO fellowship. Ludwig Institute for Cancer Research. Losanna (Switzerland): Immunology 1983−85: Post-doctoral position at the Department of Biochemistry and Molecular Biology, Harvard University, Cambridge (USA): Immunology 1986: CIBA Foundation fellowship for a stage at the Department of Pathology, St. Louis University, Missouri (USA): Immunology. Positions held From 2000: Full Professor at University of Rome “La Sapienzaâ€. Dept. of Biology and Biotechnology (former Dept. of Cell Biology and Development) 1998-2000: Associated Professor at University of Rome “La Sapienzaâ€, Dept. of Cell Biology and Development. 1992-98: Associated Professor at University of L’Aquila, Dept. of Experimental Medicine 1981-91: Researcher at University of Rome “La Sapienzaâ€
Research Interest
genetics and molecular mechanisms of autoimmune and inflammatory diseases. Main achievements have been on the dissection of structural and functional features of HLA class I and class II genes and their role in some complex diseases. More recently, interest has moved to the genetic and epigenetic control of the proliferation/differentiation of immune cells.
Publications
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Paladini F, Adinolfi V, Cocco E, Ciociola E, Tamburrano G, Cascino I, Lucantoni F, Morano S, Sorrentino R. Gender-dependent association of type 2 diabetes with the vasoactive intestinal peptide receptor 1. Gene. 2012 Feb 10;493(2):278-81.
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Nurzia E, Narzi D, Cauli A, Mathieu A, Tedeschi V, Caristi S, Sorrentino R, Böckmann RA, Fiorillo MT. Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes. PloS one. 2012 Mar 5;7(3):e32865.
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Magnacca A, Persiconi I, Nurzia E, Caristi S, Meloni F, Barnaba V, Paladini F, Raimondo D, Fiorillo MT, Sorrentino R. Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 molecules. Journal of Biological Chemistry. 2012 Aug 31;287(36):30358-67.