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Sorrentino Rosa

Ordinary Professor
Department of Biology and biotechnology
University La Sapienza
Italy

Biography

Education and training High school degree: 1969 Classic Lycee Degree BsC: Year: 1973 Field of Study: Pathology 110/110 cum laude Specialization School: 1977 Field of Study: Microbiology 70/70 cum laude Fellowships and Training: 1975-77: Laboratory of Cell Biology, CNR, Rome, Italy: Cell Biology; 1977-8: Paterson Laboratories, Christie Hospital and Holt Radium Institute in Manchester (England): Cell Biology 1981 EMBO fellowship. Ludwig Institute for Cancer Research. Losanna (Switzerland): Immunology 1983−85: Post-doctoral position at the Department of Biochemistry and Molecular Biology, Harvard University, Cambridge (USA): Immunology 1986: CIBA Foundation fellowship for a stage at the Department of Pathology, St. Louis University, Missouri (USA): Immunology. Positions held From 2000: Full Professor at University of Rome “La Sapienza”. Dept. of Biology and Biotechnology (former Dept. of Cell Biology and Development) 1998-2000: Associated Professor at University of Rome “La Sapienza”, Dept. of Cell Biology and Development. 1992-98: Associated Professor at University of L’Aquila, Dept. of Experimental Medicine 1981-91: Researcher at University of Rome “La Sapienza”

Research Interest

genetics and molecular mechanisms of autoimmune and inflammatory diseases. Main achievements have been on the dissection of structural and functional features of HLA class I and class II genes and their role in some complex diseases. More recently, interest has moved to the genetic and epigenetic control of the proliferation/differentiation of immune cells.

Publications

  • Paladini F, Adinolfi V, Cocco E, Ciociola E, Tamburrano G, Cascino I, Lucantoni F, Morano S, Sorrentino R. Gender-dependent association of type 2 diabetes with the vasoactive intestinal peptide receptor 1. Gene. 2012 Feb 10;493(2):278-81.

  • Nurzia E, Narzi D, Cauli A, Mathieu A, Tedeschi V, Caristi S, Sorrentino R, Böckmann RA, Fiorillo MT. Interaction pattern of Arg 62 in the A-pocket of differentially disease-associated HLA-B27 subtypes suggests distinct TCR binding modes. PloS one. 2012 Mar 5;7(3):e32865.

  • Magnacca A, Persiconi I, Nurzia E, Caristi S, Meloni F, Barnaba V, Paladini F, Raimondo D, Fiorillo MT, Sorrentino R. Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 molecules. Journal of Biological Chemistry. 2012 Aug 31;287(36):30358-67.

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