Stefano Cacchione
Researcher
Department of Biology and biotechnology
University La Sapienza
Italy
Biography
1985 Laurea in Biological Sciences (110/110 cum laude), Sapienza University, Rome 1987-1989 ENI fellowship, Dept. of Genetics & Molecular Biology, Sapienza University. 1995, 1999 Post-doc, Dept. of Biochemistry & Molecular Biology, University of Valencia, Spain 2001-2010 Researcher, Dept. of Genetics & Molecular Biology, Sapienza University. Since 2010 Researcher, Dept. of Biology & Biotechnology, Sapienza University.
Research Interest
Structure and function of human telomeric chromatin Interplay between telomeric nucleosomes and the human telomeric proteins TRF Epigenetic status of human telomeres Telomere organization in normal and cancer cells Structural organization of drosophila telomeres
Publications
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Franceschin M, Nocioni D, Biroccio A, Micheli E, Cacchione S, Cingolani C, Venditti A, Zizza P, Bianco A, Altieri A. Design and synthesis of a new dimeric xanthone derivative: enhancement of G-quadruplex selectivity and telomere damage. Organic & biomolecular chemistry. 2014;12(47):9572-82.
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Galati A, Micheli E, Alicata C, Ingegnere T, Cicconi A, Pusch MC, Giraud-Panis MJ, Gilson E, Cacchione S. TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization. Nucleic acids research. 2015 May 20;43(12):5824-37.
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Burla R, Carcuro M, Raffa GD, Galati A, Raimondo D, Rizzo A, La Torre M, Micheli E, Ciapponi L, Cenci G, Cundari E. AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance. PLoS genetics. 2015 Jun 25;11(6):e1005167.
