Graziella Tocco
Professor
Department of Life Sciences and the Environment
University of Cagliari
Italy
Biography
Graziella Tocco, born 27 January 1971 in Cagliari, in 1995 he graduated cum laude in Chemistry and Pharmaceutical Technology at the University of Cagliari. In January 2000 he also obtained the title of Ph.D. in "Technology and Legislation of the Drug and Bioactive Molecules" XII cycle (1996-1999), at the Department of Pharmaceutical Chemistry of the Faculty of Pharmacy of the University of Cagliari, of research also at Proff. Mauro Cinquini and Franco Cozzi, Dip. Of Organic Chemistry and Industrial-Faculty of Chemistry of the University of Milan, dealing with the synthesis supported on soluble polymer. In the period 1999 - April 2000, on behalf of the company ITALFARMACO, under the guidance of Professor Giorgio Cignarella (Faculty of Pharmacy - University of Milan), he conducted research aimed at the synthesis of new anti-inflammatory molecules. In the AA 2000-2001 he has been tutoring for the Physics Methods in Organic Chemistry at the Department of Chemistry and Pharmaceutical Technology at the Faculty of Pharmacy of the University of Cagliari. She has been a researcher (June 2000-January 2002) at the Department of Chemical Technology at the University of Cagliari. Winner of a scholarship under the Project Young Researchers, conducted research at the Proff Laboratories. Cinquini-Cozzi, dealing with the liquid phase synthesis of chiral catalytic systems directed to stereoselective reactions under catalytic conditions for phase transfer. Since February 2002 he has been a researcher in Organic Chemistry (CHIM / 06) at the Department of Life Sciences and Environmental Sciences Department of the Pharmacy Faculty of the University of Cagliari.
Research Interest
Selective regional synthesis and structural characterization of new C-sulphonylated indole derivatives and evaluation of their activity as non-nucleoside reverse transcriptase inhibitors of the HIV-1 virus. Design, realization and biological evaluation of new allosteric inhibitors of the R-Hase H function of invasive transdermal transcriptase, the key enzyme involved in replication of the HIV-1 virus. Liquid phase synthesis and immobilization on appropriately modified PEGs, molecules of chemical interest (catalytic systems) and biological (heterogeneous derivatives). This work also develops through the study of the photoluminescence properties of the anchored polymer-molecular systems (fundamental for the development of their biological activity) and the structural characterization of all derivatives and the evaluation of their biological properties.
Publications
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Begala M., Delogu G., Maccioni E., Podda G., Tocco G., Quezada E., Uriarte E., Fedrigo M.A., Favretto D., Traldi P. “Electrospray ionization tandem mass spectrometry in the characterization of isomeric benzofurocoumarins†Rapid Commun. Mass Spectrom., 2001, vol. 15, 1000.
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Annunziata R., Benaglia M., Cinquini M., Cozzi F., Tocco G. “A poly(ethylene glicol) – supported quaternari ammonium salt: an efficient, recoverable and recyclable phase – transfer catalyst†Organic Letters, 2000, 2(12), 1737 – 1739.
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Bonora G.M., Tocco G.; Caramella S.; Veronese F.M.; Pliasunova O.; Pokorovsky A.; Ivanova E.; Zarytova V. “Antisense activity of an anti – HIV oligonucleotide conjugated to linear and branched high molecular weight polyethylene glycols†Il Farmaco, 1998, 53, 634 – 637.
