Andrea Novelli

Biography

Completed studies 1965-1970 Liceo Classico Statale Michelangiolo, Florence Classical Matriculation Diploma 1970-1976 Faculty of Medicine and Surgery, University of Florence Degree in Medicine and Surgery Degree thesis "Disease-pathological differential diagnosis of lymphomas of the small intestine" 1977- 1979 School of Specialization in Oncology, University of Modena Thesis Specialization Diploma "Calcium Methylpholate in Rescue of High-dose Methotrexate Used in Human Solid Cancer" Academic positions 1.3.1977 - 20.9.1977 Chair of Chemotherapy, Institute of Pharmacology and Toxicology, University of Florence Assistant in charge 21.9.1977 - 19.9.1978 Chair of Pharmacology, Institute of Pharmacology and Toxicology Institute, University of Florence Assistant in charge Alternate 1979 - 1980 Chair of Chemotherapy, Institute of Pharmacology and Toxicology Interfaculty, University of Florence

Research Interest

The main area of ​​research falls within the scope of antimicrobial chemotherapy and concerns in particular the clinical chemotherapy evaluation of new antimicrobial drugs. Increasing the chemio-resistance of pathogens of hospital origin both Gram-positive and Gram-negative represents a major issue today for many patients, especially for some special populations (immunodeficiency, intensive care, elderly, etc.). for the last twenty years a growing commitment to research and the continuous development of new antibiotic substances. Therefore, the study of new antimicrobial drugs must necessarily be taken into account in addition to the classical determination of in vitro antimicrobial activity by evaluating the percentage of chemioresistance, also the pharmacodynamic aspects of in vitro and in vivo antibiotics, such as the post-antibiotic effect and the possible increase in leukocyte killing, which represent an important profile in determining the pharmacological characteristics of the molecule. Knowledge of these phenomena is a major contributor to the pharmacological evaluation of antimicrobial chemotherapies and can be a useful reference, together with the determination of microbiological and pharmacokinetic characteristics, to determine the correct daily dose also in terms of dose intervals. which represent an important profile in determining the pharmacological characteristics of the molecule. Knowledge of these phenomena is a major contributor to the pharmacological evaluation of antimicrobial chemotherapies and can be a useful reference, together with the determination of microbiological and pharmacokinetic characteristics, to determine the correct daily dose also in terms of dose intervals. which represent an important profile in determining the pharmacological characteristics of the molecule. Knowledge of these phenomena is a major contributor to the pharmacological evaluation of antimicrobial chemotherapies and can be a useful reference, together with the determination of microbiological and pharmacokinetic characteristics, to determine the correct daily dose also in terms of dose intervals.