Flavia Varano
Researcher
Department of Neuroscience, Area of ​​Pharmacy and Child
University of Firenze
Italy
Biography
Flavia Varano received the Bachelor of Science in Pharmaceutical Chemistry and Technology in 1995, and the PhD in Chemistry of Medicine in 1999. Both of these degrees were obtained at the University of Florence. Since 2000, Dr. Varano has been a researcher at the Faculty of Pharmacy at the University of Florence and is conducting research at the Department of Pharmaceutical Sciences.
Research Interest
His research focused first on the study and identification of central site benzodiazepine site ligands, and recently the development of both adenosine and glutamate receptor antagonists, which may represent new potential therapeutic agents for the treatment of many neurodegenerative diseases .
Publications
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Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; From Ben, Diego; Marucci, Gabriella; Buccioni, Michela; Volpini, Rosaria; De Vita, Teresa; Cavalli, Andrea; Colotta, Vittoria (2017). The 1,2,4-triazolo [4,3-a] pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 5772-5790, ISSN: 0022-2623
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Squarcialupi, Lucia; Betti, Marco; Catarzi, Daniela; Varano, Flavia; Falsini, Matteo; Ravani, Annalisa; Pasquini, Silvia; Vincenzi, Fabrizio; Salmaso, Veronica; Sturlese, Mattia; Varani, Katia; Moro, Stefano; Colotta, Vittoria (2017). The role of 5-arylalkylamino and 5-piperazino moieties on the 7-aminopyrazolo [4,3-d] pyrimidine core affecting adenosine A1 and A2A receptor affinity and selectivity profiles. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol. 32, pp. 248-263, ISSN: 1475-6366
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Daniela Poli,; Matteo Falsini,; Flavia Varano,; Marco Betti,; Katia Varani,; Fabrizio Vincenzi,; Anna Maria Pugliese,; Felicita Pedata,; Diego Dal Ben; Ajiroghene Thomas,; Ilaria Palchetti,; Francesca Bettazzi,; Daniela Catarzi,; Colotta, Vittoria (2017). Imidazo [1,2-a] pyrazine-8-amine core for the design of new adenosine receptor antagonists: Structural exploration to target the A3 and A2A subtypes. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 125, pp. 611-628, ISSN: 1768-3254
