Marco Linari
Professor
Department of Biology
University of Firenze
Italy
Biography
Marco Linari Professor of Physiology Born in Florence (December 30, 1963) 1990: Laurea in Natural Sciences 1995: PhD in Physiology Positions and Employment 1990 - 1994: Graduate Fellow (Ph.D. student), Dept. of Physiological Sciences, University of Florence , Italy 1996 - 1997: Post-Doctoral Fellow, Dept. of Physiological Sciences, University of Florence, Italy 1997 - 2001: Researcher, Dept. of Physiological Sciences, University of Florence, Italy 2001 - Associate Professor, Dept. Evolutionary Biology, of Florence, Italy 2012 - Professor, Dept. of Biology, University of Florence, Italy
Research Interest
The scientific activity is aimed at investigating the molecular mechanism of muscle contraction: how the energy from ATP hydrolysis on the catalytic site of myosin motor attached to actin is converted into force and shortening at sarcomere level. For this study, an integrated approach, involving combined mechanical, biochemical, calorimetric and X-ray diffraction experiments on single muscle fibers, is used.
Publications
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M. Linari; E. Brunello; M. Reconditi; L. Fusi; M. Caremani; T. Narayanan; G. Piazzesi; V. Lombardi; M. Irving. (2015). Force generation by skeletal muscle is controlled by mechanosensing in myosin filaments. NATURE, vol. 528, pp. 276-279, ISSN: 0028-0836
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Caremani, M.; Pinzauti, F .; Reconditi, M .; Piazzesi, G .; Stienen, G .; Lombardi, V .; Linari, M. (2016). The size and speed of the working stroke of myosin in myocardium in situ. 113, pp. 3675-3680, ISSN: 1091-6490
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Reconditi, M .; Caremani, M.; Pinzauti, F .; Powers, JD; Narayanan, T .; Stienen, GJM; Linari, M .; Lombardi, V .; Piazzesi, G. (2017). Myosin filament activation in the heart is tuned to the mechanical task. Proceedings of the National Academy of Sciences of the United States of America, vol. 114, pp. 3240-3245, ISSN: 0027-8424
