Maria Grazia Giovannini
Associate Professor
Department of Health Sciences
University of Firenze
Italy
Biography
BACKGROUND STUDIES March 1980. Graduated in Biological Sciences with a 110/110 vote and praise with an experimental thesis in Pharmacology titled "Intestinal Rat Peroxidase (EC 1.11.1.7.): Study of the histochemical localization, purification and kinetic characterization (Rapporteur: Prof. Gian Pietro Sgaragli). November 1978- March 1980. Internal student at the Research Unit of Prof. Gian Pietro Sgaragli, at the Istituto Interfacoltà of Pharmacology and Toxicology of the University of Florence. 1974-1980. Registered at the University of Florence, he attended the Degree Course in Biological Sciences, Faculty of Mathematical, Physical and Natural Sciences. July 1974. Classic maturity with final vote 57/60 at Liceo Ginnasio Michelangiolo in Florence. Known foreign languages: English spoken and written. POSITIONS RECOVERED Current position. From 1 November 2001 to today he is Researcher Confirmed at the Department of Pharmacology, Faculty of Medicine and Surgery at the University of Florence. March 1999. He was awarded a position as Co-ordinator IX Functional Qualification Level (EP 2) at the Department of Pharmacology of the University of Florence, which he held until October 31, 2001. December 1989. He won the competition for a position of Technical Officer VIII Functional Qualification Level at the Department of Preclinical and Clinical Pharmacology "Mario Aiazzi Mancini" of the University of Florence. September 1981-December 1989. He used a check issued by the CNR with notice 350.0.1, ex. L. 285, for the "Fisio-Pharmacological and Toxicological Techniques" field. During this period he has been researching at the Department of Preclinical and Clinical Pharmacology at the University of Florence, first in the Research Unit led by Prof. L. Della Corte and then in the one directed by Prof. G. Pepeu. The results are summarized in the publication by CNR "Progetto Finalizzato Medicina Preventiva e Riabilitativa".
Research Interest
Pharmacological treatments that can reduce cholinergic deficits • Modulation of ACh neuronal release from brain structures in the rat free and free to move • Study on peptide release modulation of ACh • Glutamatergic modulation of ACh release from discrete brain areas. • Studies on the effect of serotonergic agonists and antagonists on the release of cortical ACh. • Study on the effect of H3 istaminergic agonists and antagonists on the release of ACh cortical. 1998-2000 STUDY ON ERK LANDSCAPING IN LONG-TERM POTENTIATION 1998-2005 LIVE STUDY ON THE ACTIVATION OF THE CENTRAL COLINERGIC SYSTEM DURING THE LEARNING AND THE MEMORY OF CONDUCTIVE TESTS FROM 2000 TO TODAY STUDY ON INVESTMENT OF THE MAP KINASI CASCADE IN NEURODEGENERATION MECHANISMS
Publications
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Lana, Daniele; Iovino, Ludovica; Nosi, Daniele; Wenk, Gary L .; Giovannini, Maria Grazia (2016). The neuron-astrocyte-microglia triad involvement in neuroinflammatory mechanisms in the CA3 hippocampus of memory-impaired aged rats. EXPERIMENTAL GERONTOLOGY, vol. 83, pp. 71-88, ISSN: 0531-5565
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Giovannini, Maria Grazia; Lana, Daniele (2016). mTOR Involvement in Mechanisms of Memory: An Overview of Animal Studies. In: K. Maiese. Molecules to Medicine with mTOR. Translating Critical Pathways into Novel Therapeutic Strategies, pp. 169-184 Elsevier, ISBN: 978-0-12-802733-2.
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Lana, D.; Di Russo, J .; Mello, T .; Wenk, GL; Giovannini, MG (2017). Rapamycin inhibits mTOR / p70S6K activation in CA3 region of the hippocampus of the rat and impairs long term memory. NEUROBIOLOGY OF LEARNING AND MEMORY, vol. 137, pp. 15-26, ISSN: 1074-7427