Olivia Crociani
Researcher
Department of Experimental and Clinical Medicine
University of Firenze
Italy
Biography
Dr. Crociani is a Certified Researcher of General Pathology at the University of Florence. In her career she has been involved in studies aimed at defining the role of ion channels in embryonic development and their involvement in the acquisition of a neoplastic phenotype by cells of various histogenesis. In order to learn cutting-edge techniques useful to her research, she has attended bioinformatics courses and has also traveled abroad at Dr. R. Wymore's Laboratory (Department of Biological Sciences, Tulsa University, OK, USA) where has learned cellular and molecular biology skills to study the expression profile of coding genes for multiple transcripts with particular attention to their modulation. In 2001, he went to Dr. H.'s laboratory Witchel (Department of Physiology, University of Bristol, UK), where he acquired the notions necessary for the production of plasmid vectors useful for the study of both temporal and spatial expression and function. More recently, it has acquired the knowledge useful for the production of polyclonal antibodies (with the fusion protein method) and monoclonal antibodies (using the hybridoma production technique) both from the point of view of protein structure analysis and manipulation of animal models for the consequent production and characterization in vivo. Antibodies More recently, it has acquired the knowledge useful for the production of polyclonal antibodies (with the fusion protein method) and monoclonal antibodies (using the hybridoma production technique) both from the point of view of protein structure analysis and manipulation of animal models for the consequent production and characterization in vivo. Antibodies More recently, it has acquired the knowledge useful for the production of polyclonal antibodies (with the fusion protein method) and monoclonal antibodies (using the hybridoma production technique) both from the point of view of protein structure analysis and manipulation of animal models for the consequent production and characterization in vivo. Antibodiesobtained through these methods were essential for carrying out the researches involved and were marketed by national and international companies. Recently, it has also devoted itself to producing antibodies against non-protein antigens. The University of Florence acknowledged the value of monoclonal antibodies that she produced and funded three patents. Recently, he has joined the university spin-off DIVAL TOSCANA SRL as the head of the antibodies manufacturing industry.
Research Interest
monoclonal antibodies,Pathology
Publications
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Crocians O; Lastraioli E; Boni L; Pillozzi S; Romoli MR; D'Amico M; Stefanini M; Crescioli S; Taddei A; Bencini L; Bernini M; Farsi M; Beghelli S; Shoe A; Messerini L; Tomezzoli A; Vindigni C; Morgagni P; Saragoni L; Giant E; Gasperoni S; Di Costanzo F; Roviello F; De Manzoni G; Bechi P; Arcangeli A. (2014). HERG1 Channels Regulate VEGF-A Secretion in Human Gastric Cancer: Clinical Pathological Correlations and Therapeutic Implications. CLINICAL CANCER RESEARCH, pp. 1502-1512, ISSN: 1078-0432
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Lastraioli, E; Perrone, G .; Sette, A .; Fiore, A .; Crociani, O .; Manoli, S .; D'Amico, M .; Masselli, M .; Iorio, J .; Callea, M .; Borzomati, D .; Nappo, G .; Bartolozzi, F.; Santini, D .; Bencini, L .; Farsi, M .; Boni, L .; Di Costanzo, F .; Schwab, A .; Onetti Muda, A .; Coppola, R .; Arcangeli, A. (2015). HERG1 channels drive tumor malignancy and may serve as prognostic factor in pancreatic ductal adenocarcinoma. BRITISH JOURNAL OF CANCER, vol. 112, pp. 1076-1087, ISSN: 0007-0920
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Gabbiani, Chiara; Followed by Alessandro; Marchetti, Lorella; Casini, Angela; Leoni, Piero; Pillozzi, Serena; Crocians, Olivia; Bartoli, Gianluca; Messori, Luigi (2016). Potent in vitro antiproliferative properties for a triplatinum cluster towards triple negative breast cancer cells. JOURNAL OF INORGANIC BIOCHEMISTRY, vol. 163, pp. 318-322, ISSN: 0162-0134