Rosanna Matucci
Researcher
Department of Neuroscience, Area of ​​Pharmacy and Child
University of Firenze
Italy
Biography
STUDIES: 1974-1980 Degree in Pharmaceutical Chemistry and Technology, University of Florence PROFESSIONAL EXPERIENCES: September 1980-March1981: Practical internship for admission to the state examination for enrollment in the Pharmacist profession. 1981: Enrollment in Pharmacy Profession 1983-1989: Professional Training Certification of CNR, Department of Pharmacology in Florence. 1980-2000: attended specialization courses and national and international schools 1990-2001: Technical Officer, Department of Pharmacology of Florence November 2001-2004: Researcher confirmed for the Faculty of Medicine and Surgery of the University of Florence, Department of Pharmacology . 2004-today: Researcher confirmed for the Faculty of Pharmacy of the University of Florence, Department of Pharmacology. 2006-today: Aggregate Professor for Pharmacy faculty Other Titles Member of the Conference Organizing Committee "Sulfur amino acids, peptides and related compounds" (San Miniato, Florence, October 6-9, 1986) Member of the Italian Society of Pharmacology
Research Interest
Cellular mechanisms of cardiac arrhythmias; Antiarrhythmic drugs - caused by hypoxia and hypoxia models plus cardiac monitoring in experimental animals and the involvement of free oxygen radicals: binding studies of dihydropyridines - radical species involved in the damage caused by reperfusion following a period of ischemia in human models (spotted hearts): effect of calcium antagonists on radicals studied by spin (EPR) techniques of neuropeptide Y (NPY) action in GTPasic activation in the rat ventricle: evidence for a direct stimulation of Gi proteins - binding binders for beta adrenergic receptors in human and rat cardiac and myocardium in cardiovascular diseases. -columnboration with research centers for the study of muscarinic receptors in animal tissues and cell lines that express solidly the muscarinic human receptors (m1-m5), allosteric mechanisms
Publications
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Carosati, Emanuele; Cosimelli, Barbara; Ioan, Pierfranco; Severi, Elda; Katneni, Kasiram; Chiu, Francis CK; Saponara, Simona; Fusi, Fabio; Frosini, Maria; Matucci, Rosanna; Micucci, Matteo; Chiarini, Alberto; Spinelli, Domenico; Budriesi, Roberta (2016). Understanding Oxadiazolothiazinone Biological Properties: Negative Inotropic Activity versus Cytochrome P450-Mediated Metabolism. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 3340-3352, ISSN: 0022-2623
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Del Bello, Fabio; Bonifazi, Alessandro; Giorgioni, Gianfabio; Petrelli, Riccardo; Quaglia, Wilma; Altomare, Angela; Falcicchio, Aurelia; Matucci, Rosanna; Vistoli, Giulio; Piergentili, Alessandro (2017). Novel muscarinic acetylcholine receptor hybrid ligands incorporating quinuclidine and 1,4-dioxane fragments. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 137, pp. 327-337, ISSN: 0223-5234
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April, Silvio; Canavesi, Rossana; Matucci, Rosanna; Bellucci, Cristina; Del Grosso, Erika; Grosa, Giorgio (2017). New insights into the metabolism of Oxybutynin: evidence of N-oxidation of propargylamine moiety and rearrangement to enaminoketone. XENOBIOTICS, pp. 1-25-25, ISSN: 0049-8254
