Alessandra Modesti

Biography

Alessandra Modesti graduated in Pharmacy at the University of Florence on 16/7/1984 with a vote of 110/110. From that date he continued to attend the Institute of Biological Chemistry, collaborating with ongoing research. In 1991 he received his Ph.D. in Biochemistry at the University of Florence, and in 1993 received his PhD in Biochemistry at the Cranfield Institute of Technology (GB) after a three-year period at the Center. From April to June 1994 he conducted research at the Instituto de Investigaciones Biomedica IIB in Madrid (Spain) in the laboratory led by Prof. Carlos Gancedo using a scholarship from the Inter-University Biotechnology Committee (CIB). Since 1/7/1995 he has been included in the role of university researchers (Scientific-disciplinary sector E05A, Biochemistry) and in this role he has continued his full-time work at the Department of Biochemical Sciences of the University of Florence until October 31, 1999. From 1/11/2000 is Associate Professor for the Scientific-disciplinary BIO / 13 (Applied Biology) at the Faculty of Medicine and Surgery at the University of Florence. Scientific activity began with the study of the primary structure of two phosphomonoidrolases. Subsequently, the protein-approach approach has been using classic molecular biology techniques to obtain recombinant proteins from bacterial and yeast proteins. The yeast study provided for the expression of a tyrosine phosphatase and a negative dominant mutant to evaluate the variation of phosphoprotectomy in S.cerevisiae. The main research lines currently underway concern the differential study of proteome in S.cerevisiae yeast cells subjected to different types of stimuli. This organism has been widely used as a model for numerous studies also aimed at understanding complex phenomena present in pluricellular organisms. More recently, it is also studying the proteomic techniques of evaluating the oxidation of plasma proteins during exercise in trained subjects.

Research Interest

Applied Biology