Flavia Varano
Researcher
Department of Neuroscience, Area of ​​Pharmacy and Child
University of Florence
Italy
Biography
Flavia Varano received the Bachelor of Science in Pharmaceutical Chemistry and Technology in 1995, and the PhD in Chemistry of Medicine in 1999. Both of these degrees were obtained at the University of Florence. Since 2000, Dr. Varano has been a researcher at the Faculty of Pharmacy at the University of Florence and is conducting research at the Department of Pharmaceutical Sciences. His research focused first on the study and identification of central site benzodiazepine site ligands, and recently the development of both adenosine and glutamate receptor antagonists, which may represent new potential therapeutic agents for the treatment of many neurodegenerative diseases .
Research Interest
Pharmaceutical chemistry
Publications
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Flavia Varano; Daniela Catarzi; Fabrizio Vincenzi; Marco Betti; Matteo Falsini; Annalisa Ravani; Pier Andrea Borea; Vittoria Colotta; Katia Varani (2016). Design, synthesis, and pharmacological characterization of 2‑(2- furanyl)thiazolo[5,4‑d]pyrimidine-5,7-diamine derivatives: new highly potent A2A adenosine receptor inverse agonists with antinociceptive activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 59, pp. 10564-10576, ISSN:0022-2623
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Lucia Squarcialupi; Matteo Falsini; Daniela Catarzi; Flavia Varano; Marco Betti; Katia Varani; Fabrizio Vincenzi; Diego Dal Ben; Catia Lambertucci; Rosaria Volpini; Vittoria Colotta (2016). Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 24, pp. 2794-2808, ISSN:1464-3391
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Falsini, Matteo; Squarcialupi, Lucia; Catarzi, Daniela; Varano, Flavia; Betti, Marco; Di Cesare Mannelli, Lorenzo; Tenci, Barbara; Ghelardini, Carla; Tanc, Muhammet; Angeli, Andrea; Supuran, Claudiu T.; Colotta, Vittoria (2017). 3-Hydroxy-1H-quinazoline-2,4-dione as a New Scaffold to Develop Potent and Selective Inhibitors of the Tumor-Associated Carbonic Anhydrases IX and XII. JOURNAL OF MEDICINAL CHEMISTRY, vol. 60, pp. 6428-6439, ISSN:0022-2623
