Giovanna Caderni

Biography

Giovanna Caderni (Florence, 1955) graduated in 1979 in Biological Sciences at the University of Florence with the highest praise and praise. He was appointed National Research Council (1982-1989), Graduated Technician and then Researcher at the University of Florence (1990-2002). Since 2002 he is Associate Professor in Pharmacology at the Faculty of Pharmacy of the same University. In 1986-1987 he was a post-doctoral fellow at the Ludwig Institute for Cancer Research in Toronto Canada. He studied the genotoxic effects of food mutagens and the effect of dietary variations on carcinogenicity in experimental animals and humans, demonstrating that diet carbohydrates affect bowel proliferation and therefore carcinogenicity. Hgiven a significant contribution in the field of preneoplastic lesions by first identifying the presence in the colon of rodents treated with colon-specific mucin-depleted calf mice (MDFs). It has shown that these lesions are dysplastic, related to carcinogenesis, mutated into crucial cancer genes ( Apc , β-catenine and K-ras) and are present in high risk patients for colon cancer. She was responsible for research projects funded by the European Community ("Synbiotics and Cancer Prevention in Humans" (QLRT -1999-00346). In 2005-2007 and 2010-2011, it was funded by the American Institute for Cancer Research and the World Cancer Research Fund for the research projects on the characterization of MDF lesions and on the relationship between carcinogenesis and inflammation recently funded by the Istituto Toscano Tumori (ITT) for a research on the chemopreventive effects of a combination of drugs and natural compounds on intestinal carcinogenesis that will be studied in new genetic model for the study of colon cancer .

Research Interest

Scientific interests are mainly focused on the study of intestinal carcinogenesis with particular attention to the early phases of this process and the influence of diet components.