Lido Calorini

Biography

Born in San Miniato on April 25, 1953-1972, he enrolled in the Faculty of Medicine and Surgery at the University of Florence. 1979 graduated in Medicine and Surgery at the University of Florence, with a 110 / 110.1979-82 vote attending the School of Specialization in Clinical and Laboratory Hematology at the Faculty of Medicine and Surgery at the University of Florence, and obtains a specialist diploma, discussing a thesis titled "Participation of the Factors of the Emotional System in the Metastatic Process" .1980-81 plays Military Service as a Subordinate Medical Officer at the Transfusion Center of the Ministry of Defense, with headquarters in Florence1981-89 CNR Assignee pursuant to Law 285/771988, holds a Ph.D. thesis entitled "Role of Cellular Cell Lipids in the Metastatic Dissolution Process" 1990 Role Technical Officer at the Institute of General Pathology of the University of Florence1991 -92 Research Associate at the Department of Radiation Oncology, Division of Radiation and Cancer Biology at Tufts University School of Medicine in Boston, MA, USA, receiving a scholarship from the Italian Cancer Research Research Research Associate at the " Department of Medicine, Division of Hematology-Oncology "of Harvard Medical School in Boston, MA, USA2000 University Researcher in General Pathology at the Faculty of Medicine and Surgery of the University of Florence 2001 Associate Professor of General Pathology at the Faculty of Medicine and Surgery at the University of Florence Prof. Lido Calorini has focused since the beginning of his research activity in investigating the mechanisms responsible for the metastatic tumor diffusion process. In particular, he faced the study of complex relationships that metastatic cells establish to their advantage with host inflammatory cells (macrophages and fibroblasts). More recently, Prof. Calorini has extended her interest in the tumor microenvironment by studying the contribution of extracellular medium acidity to local invasive mechanisms and colonization in the secondary organs. Interest in the acidity of the extracellular medium of tumors is also due to the fact that proton pump inhibitors (exomeprazole), known anti-acid drugs used in clinical practice, may represent new antineoplastic drugs. Another interest of Prof. Calorini concerns the development of new integrin antagonists useful for the control of tumor angiogenesis and preclinical PET investigations.

Research Interest

Tumor microenvironment, macrophages, fibroblasts, mesenchymal stem cells and neoplastic progression · Acidity of the tumor micro-environment and angiogenesis, invasiveness and metastasis · Integral RGD antagonists and PET imaging " · Integral RGD antagonists and TGFbeta switch control in tumors