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Paola Failli

Professor
Department of Neuroscience, Area of ​​Pharmacy and Child
University of Florence
Italy

Biography

Laurea in Pharmacy (University of Florence) on 14 / XI / 1978 with 110/110 votes. From October 1979 to July 1980 he obtained a scholarship from the Federal Polytechnic of Zurich (CH), which was renewed until September 1981. From February 1982 to November 1984, he is a member of the firm FIRMA - Via Starnina, 75 - Florence as a researcher. - From December 1984 to 1985, she has been awarded a PhD for Pharmacology Specialization at the Department of Preclinical and Clinical Pharmacology "M. Aiazzi Mancini" - In the academic year 1985/86 she won a position in the PhD in Pharmacology and Toxicology at the Department of Preclinical and Clinical Pharmacology "M. Aiazzi Mancini" - In July 1990 he obtained the title of Doctor of Pharmacology and Toxicology Research with a final dissertation titled "Interpretation of pharmacological effects through calcium measurements and intracellular pH". - In July 1991 he won the competition for 1 position as a university researcher at the Faculty of Medicine and Surgery of the University of Florence, E07X (current BIO14), Pharmacology, and since November 13, 1991 he has been employed as a researcher at the Faculty of Medicine Surgery at the Department of Preclinical and Clinical Pharmacology "M. Aiazzi Mancini" of the University of Florence. - In December 1995 he received the confirmation as a researcher - Since November 13, 1994 he is a confirmed university researcher at the Faculty of Medicine and Surgery at the Department of Preclinical and Clinical Pharmacology "M. Aiazzi Mancini" of the University of Florence. - In February 2002 he wins a competition for associate professor and is called by the Faculty of Medicine and Surgery at the University of Florence on March 17, 2002. - From 1 November 2002 (academic year 2002/03) takes up as professor associate of the Faculty of Medicine and Surgery of the University of Florence, disciplinary sector BIO14 Pharmacology. - Gets Confirmation as Associate Professor since 1st November 2005 (academic year 2005/06). - Current academic position: Associate Professor in the BIO14 (Pharmacology) Department of the Faculty of Medicine and Surgery, with work at the Department of Preclinical and Clinical Pharmacology "Mario Aiazzi Mancini" of the University of Florence Scientific Activity: Dr. Paola Failli's scientific activity focuses on the study of pharmacology regulation of second intracellular messengers, especially regarding intracellular calcium ion and cyclic nucleotides. The themes discussed are related to the physiopathology and pharmacology of autacoids in the cardiovascular system. The scientific activity is documented by 59 publications in international journals with referees and numerous communications and reports to international and national congresses. Didactic activity: • Didactic activity in the BIO14 Pharmacology field for the Integrated Pharmacology Course at the degree course in Medicine and Surgery from the 2002/03 academic year (CF 4); • Responsible and lecturer of the ADE-80 Course Dynamic intracellular ion measurement in Pharmacological Research 2004/05 academic year for Medical Students • Didactic activity in the BIO14 Pharmacology for Second Level Master's Degree "Thrombosis: from Molecular Biology to Pharmacology" Academic Year 2004/05, 2005/06, 2006/07, 2007/08. • Didactic activity in BIO14 Pharmacology for the First Level Master in General Surgery for Nurses in AI. 2002/03 and 2007/2008; Intensive Therapy and Resuscitation, Emergency-Urgency in Academic Years 2006/2007 and 2007/08. • Didactic activity in the School of Specialization in Pharmacology and Allergology of the Faculty of Medicine and Surgery. • Didactic activity at the Doctoral School of Pharmacology at the Faculty of Medicine and Surgery. • Relationship to Pharmacology Teaching (0095840), Integrated Course 0095836 (MEDICINE AND GENERAL SURGERY, PHARMACOLOGY AND ANESTHESIOLOGY) in the Degree Course in Nursing, Empoli Headquarters from the 2002/03 academic year (CF2); • Dependence on Pharmacology Teaching (0095885) Integrated Course 0095884 (URGEN MEDICINE AND INTENSIVE THERAPY AND NATURAL CLINICAL APPLICATION) in the Nursing Degree Course, Empoli University, from the 2002/03 academic year (CF0.5) ; • Depending on the teaching of Pharmacology (0095987) integrated course 0095984 (ANESTHESIA AND ANALGESIA IN OSTETRIC, CLINICAL PHARMACOLOGY, TOXICOLOGY) in the Degree Course in Obstetrics, Headquarters of Empoli from the academic year 2004/05 to date (CF1); • Bachelor's Thesis Rector (Faculty of Medicine and Surgery, Pharmacy and Mathematical, Physical and Natural Sciences, Biological Sciences)

Research Interest

Pharmacology

Publications

  • Nistri, S; By Cesare Mannelli, L; Ghelardini, C; Zanardelli, M.; Bani, D; Failli, P. (2015). Pretreatment with relaxin does not restore no-mediated modulation of calcium signal in coronary endothelial cells isolated from spontaneously hypertensive rats. MOLECULES, vol. 20, pp. 9524-9535, ISSN: 1420-3049

  • Zanardelli, Matteo; Micheli, Laura; Nicolai, Raffaella; Failli, Paola; Ghelardini, Carla; By Cesare Mannelli, Lorenzo (2015). Different apoptotic pathways activated by oxaliplatin in primary astrocytes vs. colo-rectal cancer cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 16, pp. 5386-5399, ISSN: 1661-6596

  • By Cesare Mannelli, Lorenzo; Tenci, Barbara; Zanardelli, Matteo; Failli, Paola; Ghelardini, Carla (2015). α7 Nicotinic Receptor Promotes Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity. NEURAL PLASTICITY, vol. 2015, pp. 396908-396917, ISSN: 2090-5904

  • Spinelli, Valentina; Vona, Alessia; Corti, Francesca; Diolaiuti, Lorenzo; Zanardelli, Matteo; Sartiani, Laura; Failli, Paola (2016). Role of Nitric Oxide, Nitric Oxide Synthase, Soluble Guanylyl Cyclase, and CGMP-Dependent Protein Kinase I in Mouse Stem Cell Cardiac Development. STEM CELLS INTERNATIONAL, vol. 2016, pp. 1-10, ISSN: 1687-9678

  • By Cesare Mannelli, Lorenzo; Zanardelli, Matteo; Landini, Ida; Pacini, Alessandra; Ghelardini, Carla; Mini, Enrico; Bencini, Andrea; Valtancoli, Barbara; Failli, Paola (2016). Effect of the SOD mimetic MnL4 on in vitro and in vivo oxaliplatin toxicity: Possible aid in chemotherapy-induced neuropathy. FREE RADICAL BIOLOGY & MEDICINE, vol. 93, pp. 67-76, ISSN: 0891-5849

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